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XB-ART-7503
J Biol Chem 2002 Jul 05;27727:24735-43. doi: 10.1074/jbc.M107669200.
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Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart.

Toko H , Zhu W , Takimoto E , Shiojima I , Hiroi Y , Zou Y , Oka T , Akazawa H , Mizukami M , Sakamoto M , Terasaki F , Kitaura Y , Takano H , Nagai T , Nagai R , Komuro I .


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Csx/Nkx2-5, which is essential for cardiac development of the embryo, is abundantly expressed in the adult heart. We here examined the role of Csx/Nkx2-5 in the adult heart using two kinds of transgenic mice. Transgenic mice that overexpress a dominant negative mutant of Csx/Nkx2-5 (DN-TG mice) showed degeneration of cardiac myocytes and impairment of cardiac function. Doxorubicin induced more marked cardiac dysfunction in DN-TG mice and less in transgenic mice that overexpress wild type Csx/Nkx2-5 (WT-TG mice) compared with non-transgenic mice. Doxorubicin induced cardiomyocyte apoptosis, and the number of apoptotic cardiomyocytes was high in the order of DN-TG mice, non-transgenic mice, and WT-TG mice. Overexpression of the dominant negative mutant of Csx/Nkx2-5 induced apoptosis in cultured cardiomyocytes, while expression of wild type Csx/Nkx2-5 protected cardiomyocytes from doxorubicin-induced apoptotic death. These results suggest that Csx/Nkx2-5 plays a critical role in maintaining highly differentiated cardiac phenotype and in protecting the heart from stresses including doxorubicin.

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Species referenced: Xenopus
Genes referenced: nkx2-5