Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-7433
Bioorg Med Chem Lett 2002 Apr 08;127:1023-6. doi: 10.1016/s0960-894x(02)00101-4.
Show Gene links Show Anatomy links

The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.

Hewawasam P , Gribkoff VK , Pendri Y , Dworetzky SI , Meanwell NA , Martinez E , Boissard CG , Post-Munson DJ , Trojnacki JT , Yeleswaram K , Pajor LM , Knipe J , Gao Q , Perrone R , Starrett JE .


???displayArticle.abstract???
3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can be isolated using chiral HPLC or prepared by employing chiral resolution. Cloned maxi-K channels are opened by 1, which demonstrates a brain/plasma ratio >9 in rats.

???displayArticle.pubmedLink??? 11909708
???displayArticle.link??? Bioorg Med Chem Lett