XB-ART-7250
Dev Cell
2002 Apr 01;24:381-2. doi: 10.1016/s1534-5807(02)00155-7.
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Chromosome segregation: playing polo in prophase.
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During mitosis, in most eukaryotes, cohesin is removed from chromosomes in two steps. A paper in the March issue of Molecular Cell identifies Polo-like kinase as a key regulator for the first step that releases much of cohesin during prophase.
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References :
Nasmyth,
Splitting the chromosome: cutting the ties that bind sister chromatids.
2000, Pubmed