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XB-ART-6823
Biochem Biophys Res Commun 2002 Jul 26;2954:945-51. doi: 10.1016/s0006-291x(02)00757-x.
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Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA.

Yoshida Y , Izumi H , Ise T , Uramoto H , Torigoe T , Ishiguchi H , Murakami T , Tanabe M , Nakayama Y , Itoh H , Kasai H , Kohno K .


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Mitochondrial transcription factor A (mtTFA) is necessary for both transcription and maintenance of mtDNA, and is also one of the high mobility group (HMG) proteins that preferentially binds to cisplatin-damaged DNA. In this study we confirmed the preferential binding of mtTFA to cisplatin-damaged DNA, and also discovered that mtTFA binds to oxidatively damaged DNA. The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG. Our findings suggest that mtTFA plays an important role in the recognition of oxidative DNA damage.

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Species referenced: Xenopus
Genes referenced: tfam