Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Regional differences in distribution and functional expression of small-conductance Ca2+-activated K+ channels in rat brain.
Sailer CA
,
Hu H
,
Kaufmann WA
,
Trieb M
,
Schwarzer C
,
Storm JF
,
Knaus HG
.
???displayArticle.abstract???
Small-conductance Ca2+-activated K+ (SK) channels are important for excitability control and afterhyperpolarizations in vertebrate neurons and have been implicated in regulation of the functional state of the forebrain. We have examined the distribution, functional expression, and subunit composition of SK channels in rat brain. Immunoprecipitation detected solely homotetrameric SK2 and SK3 channels in native tissue and their constitutive association with calmodulin. Immunohistochemistry revealed a restricted distribution of SK1 and SK2 protein with highest densities in subregions of the hippocampus and neocortex. In contrast, SK3 protein was distributed more diffusely in these brain regions and predominantly expressed in phylogenetically older brain regions. Whole-cell recording showed a sharp segregation of apamin-sensitive SK current within the hippocampal formation, in agreement with the SK2 distribution, suggesting that SK2 homotetramers underlie the apamin-sensitive medium afterhyperpolarizations in rat hippocampus.
Amaral,
Neurons, numbers and the hippocampal network.
1990, Pubmed
Amaral,
Neurons, numbers and the hippocampal network.
1990,
Pubmed
Bond,
Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.
2000,
Pubmed
Bowden,
Somatic colocalization of rat SK1 and D class (Ca(v)1.2) L-type calcium channels in rat CA1 hippocampal pyramidal neurons.
2001,
Pubmed
Faber,
Physiological role of calcium-activated potassium currents in the rat lateral amygdala.
2002,
Pubmed
Grunnet,
Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels.
2001,
Pubmed
,
Xenbase
Grunnet,
Pharmacological modulation of SK3 channels.
2001,
Pubmed
Haas,
Noradrenaline blocks potassium conductance in rat dentate granule cells in vitro.
1987,
Pubmed
Hirschberg,
Gating of recombinant small-conductance Ca-activated K+ channels by calcium.
1998,
Pubmed
,
Xenbase
Hotson,
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons.
1980,
Pubmed
Hu,
Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release.
2001,
Pubmed
Ishii,
Determinants of apamin and d-tubocurarine block in SK potassium channels.
1997,
Pubmed
,
Xenbase
Keen,
Domains responsible for constitutive and Ca(2+)-dependent interactions between calmodulin and small conductance Ca(2+)-activated potassium channels.
1999,
Pubmed
,
Xenbase
Knaus,
Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals.
1996,
Pubmed
Knaus,
Characterization of tissue-expressed alpha subunits of the high conductance Ca(2+)-activated K+ channel.
1995,
Pubmed
Koschak,
[125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels.
1997,
Pubmed
,
Xenbase
Koschak,
Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom.
1998,
Pubmed
Köhler,
Small-conductance, calcium-activated potassium channels from mammalian brain.
1996,
Pubmed
,
Xenbase
Lai,
Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization.
1977,
Pubmed
Lancaster,
Calcium-dependent current generating the afterhyperpolarization of hippocampal neurons.
1986,
Pubmed
Lancaster,
Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones.
1987,
Pubmed
Madison,
Cyclic adenosine 3',5'-monophosphate mediates beta-receptor actions of noradrenaline in rat hippocampal pyramidal cells.
1986,
Pubmed
Meera,
A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.
2000,
Pubmed
,
Xenbase
Partridge,
Control of cell function by neuronal calcium-activated nonselective (CAN) cation channels.
1993,
Pubmed
Pedarzani,
PKA mediates the effects of monoamine transmitters on the K+ current underlying the slow spike frequency adaptation in hippocampal neurons.
1993,
Pubmed
Pennefather,
Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells.
1985,
Pubmed
Sah,
Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation.
1996,
Pubmed
Shah,
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines.
2000,
Pubmed
,
Xenbase
Shah,
Ca(2+) channels involved in the generation of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurons.
2000,
Pubmed
Shah,
Clotrimazole analogues: effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones.
2001,
Pubmed
Shmukler,
Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1.
2001,
Pubmed
Stocker,
An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons.
1999,
Pubmed
Stocker,
Differential distribution of three Ca(2+)-activated K(+) channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system.
2000,
Pubmed
Storm,
Potassium currents in hippocampal pyramidal cells.
1990,
Pubmed
Storm,
An after-hyperpolarization of medium duration in rat hippocampal pyramidal cells.
1989,
Pubmed
Storm,
Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells.
1987,
Pubmed
Strøbaek,
Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.
2000,
Pubmed
Tacconi,
Distribution of the messenger RNA for the small conductance calcium-activated potassium channel SK3 in the adult rat brain and correlation with immunoreactivity.
2001,
Pubmed
Vergara,
Calcium-activated potassium channels.
1998,
Pubmed
Vázquez,
Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel.
1990,
Pubmed
Wang,
Calcium-activated potassium conductances in retinal ganglion cells of the ferret.
1998,
Pubmed
Williamson,
Characterization of an early afterhyperpolarization after a brief train of action potentials in rat hippocampal neurons in vitro.
1990,
Pubmed
Wouterlood,
Anterograde neuroanatomical tracing with Phaseolus vulgaris-leucoagglutinin combined with immunocytochemistry of gamma-amino butyric acid, choline acetyltransferase or serotonin.
1988,
Pubmed
Xia,
Mechanism of calcium gating in small-conductance calcium-activated potassium channels.
1998,
Pubmed
,
Xenbase