Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-60527
Nat Commun 2024 Jan 17;151:535. doi: 10.1038/s41467-023-44522-2.
Show Gene links Show Anatomy links

Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance.

Tung A , Sperry MM , Clawson W , Pavuluri A , Bulatao S , Yue M , Flores RM , Pai VP , McMillen P , Kuchling F , Levin M .


???displayArticle.abstract???
Information for organismal patterning can come from a variety of sources. We investigate the possibility that instructive influences for normal embryonic development are provided not only at the level of cells within the embryo, but also via interactions between embryos. To explore this, we challenge groups of embryos with disruptors of normal development while varying group size. Here, we show that Xenopus laevis embryos are much more sensitive to a diverse set of chemical and molecular-biological perturbations when allowed to develop alone or in small groups, than in large groups. Keeping per-embryo exposure constant, we find that increasing the number of exposed embryos in a cohort increases the rate of survival while incidence of defects decreases. This inter-embryo assistance effect is mediated by short-range diffusible signals and involves the P2 ATP receptor. Our data and computational model emphasize that morphogenesis is a collective phenomenon not only at the level of cells, but also of whole bodies, and that cohort size is a crucial variable in studies of ecotoxicology, teratogenesis, and developmental plasticity.

???displayArticle.pubmedLink??? 38233424
???displayArticle.pmcLink??? PMC10794468
???displayArticle.link??? Nat Commun
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: mrc1
GO keywords: embryo development [+]


???attribute.lit??? ???displayArticles.show???
References [+] :
Abbracchio, International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. 2006, Pubmed