Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Virol
2003 Jan 01;771:37-44. doi: 10.1128/jvi.77.1.37-44.2003.
Show Gene links
Show Anatomy links
Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing.
Denicourt C
,
Kozak CA
,
Rassart E
.
???displayArticle.abstract???
The Graffi murine leukemia virus is a nondefective ecotropic retrovirus that was originally reported to induce myeloid leukemia in some strains of mice (A. Graffi, Ann. N.Y. Acad. Sci. 68:540-558, 1957). Using provirus-flanking sequences as DNA probes, we identified a new common retroviral integration site called Gris1 (for Graffi integration site 1). Viral integrations in Gris1 were detected in 13% of the tumors analyzed. The Gris1 locus was mapped to the distal region of mouse chromosome 6, 85 kb upstream of the cyclin D2 gene. Such viral integration in Gris1 causes overexpression of the normal 6.5-kb major transcript of cyclin D2 but also induces the expression of a new, alternatively spliced 1.1-kb transcript from the cyclin D2 gene that encodes a truncated cyclin D2 of 17 kDa. The expression of this 1.1-kb transcript is specific to tumors in which Gris1 is rearranged but is also detected at low levels in normal tissue.
Adamson,
The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents.
1991, Pubmed
Adamson,
The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents.
1991,
Pubmed
Bartkova,
D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy.
1999,
Pubmed
Bates,
CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.
1994,
Pubmed
Betticher,
Alternate splicing produces a novel cyclin D1 transcript.
1995,
Pubmed
Coffin,
Retroviral Pathogenesis
1997,
Pubmed
Datar,
The Drosophila cyclin D-Cdk4 complex promotes cellular growth.
2000,
Pubmed
Denicourt,
Oncogene activation in myeloid leukemias by Graffi murine leukemia virus proviral integration.
1999,
Pubmed
Dowdy,
Physical interaction of the retinoblastoma protein with human D cyclins.
1993,
Pubmed
Ewen,
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.
1993,
Pubmed
Ezhevsky,
Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo.
2001,
Pubmed
GRAFFI,
Chloroleukemia of mice.
1957,
Pubmed
Hanna,
The Vin-1 gene, identified by provirus insertional mutagenesis, is the cyclin D2.
1993,
Pubmed
Hansen,
Activation of Hex and mEg5 by retroviral insertion may contribute to mouse B-cell leukemia.
1999,
Pubmed
,
Xenbase
Hirai,
Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1.
1996,
Pubmed
Huard,
Cerebellar histogenesis is disturbed in mice lacking cyclin D2.
1999,
Pubmed
Inaba,
Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.
1992,
Pubmed
Jonkers,
Retroviral insertional mutagenesis as a strategy to identify cancer genes.
1996,
Pubmed
Kerkhoff,
Cyclin D2 and Ha-Ras transformed rat embryo fibroblasts exhibit a novel deregulation of cell size control and early S phase arrest in low serum.
1995,
Pubmed
Keyomarsi,
Deregulation of cyclin E in breast cancer.
1995,
Pubmed
Kiyokawa,
Cloning of a D-type cyclin from murine erythroleukemia cells.
1992,
Pubmed
Kozak,
Genetic mapping of a cloned sequence responsible for susceptibility to ecotropic murine leukemia viruses.
1990,
Pubmed
Lammie,
Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasms.
1992,
Pubmed
Li,
Alternatively spliced cyclin C mRNA is widely expressed, cell cycle regulated, and encodes a truncated cyclin box.
1996,
Pubmed
Matsushime,
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle.
1991,
Pubmed
Matsushime,
Novel mammalian cyclins (CYL genes) expressed during G1.
1991,
Pubmed
Matsushime,
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.
1992,
Pubmed
Meyer,
Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression.
2000,
Pubmed
Meyerson,
Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
1994,
Pubmed
Ohtsubo,
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition.
1995,
Pubmed
Ru,
Graffi murine leukemia virus: molecular cloning and characterization of the myeloid leukemia-inducing agent.
1993,
Pubmed
Sherr,
D-type cyclins.
1995,
Pubmed
Sicinski,
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis.
1996,
Pubmed
Sola,
Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively.
1988,
Pubmed
Sørensen,
Amplification and sequence analysis of DNA flanking integrated proviruses by a simple two-step polymerase chain reaction method.
1993,
Pubmed
Sørensen,
Sequence tags of provirus integration sites in DNAs of tumors induced by the murine retrovirus SL3-3.
1996,
Pubmed
Taïeb,
Xenopus cyclin D2: cloning and expression in oocytes and during early development.
1996,
Pubmed
,
Xenbase
Teramoto,
Expression of cyclin D2 and D3 in lymphoid lesions.
1999,
Pubmed
Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed
Tremblay,
Identification of a novel gene, Vin-1, in murine leukemia virus-induced T-cell leukemias by provirus insertional mutagenesis.
1992,
Pubmed
Wolff,
Contribution of oncogenes and tumor suppressor genes to myeloid leukemia.
1997,
Pubmed
van Lohuizen,
Tumorigenesis by slow-transforming retroviruses--an update.
1990,
Pubmed
