Jach D , Cheng Y , Prica F , Dumartin L , Crnogorac-Jurcevic T .

Wellcome Trust

Aberger, Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2. 1998, Pubmed, Xenbase

Aberger, Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2. 1998, Pubmed , Xenbase
Aiello, Echoes of the embryo: using the developmental biology toolkit to study cancer. 2016, Pubmed
Alavi, High expression of AGR2 in lung cancer is predictive of poor survival. 2015, Pubmed
Arumugam, New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice. 2015, Pubmed
Bergström, AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus. 2014, Pubmed
Boj, Organoid models of human and mouse ductal pancreatic cancer. 2015, Pubmed
Broustas, RAD9A promotes metastatic phenotypes through transcriptional regulation of anterior gradient 2 (AGR2). 2019, Pubmed
Bu, Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells. 2013, Pubmed
Bu, The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection. 2011, Pubmed
Chen, Anterior gradient 2: a novel sensitive tumor marker for metastatic oral cancer. 2013, Pubmed
Chen, Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells. 2012, Pubmed
Chen, Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. 2010, Pubmed
Chung, Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma. NULL, Pubmed , Xenbase
Cocce, The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. 2019, Pubmed
Dahal Lamichane, AGR2 is a target of canonical Wnt/β-catenin signaling and is important for stemness maintenance in colorectal cancer stem cells. 2019, Pubmed
Delom, The anterior gradient-2 interactome. 2020, Pubmed
Di Maro, Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells. 2014, Pubmed
Dong, The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation. 2011, Pubmed
Dumartin, AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D. 2011, Pubmed
Dumartin, ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation. 2017, Pubmed
Edgell, Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer. 2010, Pubmed
Fagerberg, Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. 2014, Pubmed
Fessart, Extracellular AGR2 triggers lung tumour cell proliferation through repression of p21CIP1. 2021, Pubmed
Fletcher, hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. 2003, Pubmed , Xenbase
Fritzsche, Prognostic relevance of AGR2 expression in breast cancer. 2006, Pubmed
Fritzsche, Expression of AGR2 in non small cell lung cancer. 2007, Pubmed
Galligan, The human protein disulfide isomerase gene family. 2012, Pubmed
Gong, AGR2-induced glucose metabolism facilitated the progression of endometrial carcinoma via enhancing the MUC1/HIF-1α pathway. 2020, Pubmed
Guo, Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization. 2017, Pubmed
Guo, A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth. 2016, Pubmed
Gupta, Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. 2013, Pubmed
Gupta, AGR2 gene function requires a unique endoplasmic reticulum localization motif. 2012, Pubmed
Hengel, Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance. 2011, Pubmed
Higa, Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis. 2011, Pubmed
Ho, Bladder cancer cells secrete while normal bladder cells express but do not secrete AGR2. 2016, Pubmed
Hong, Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells. 2021, Pubmed
Hong, AGR2 expression is regulated by HIF-1 and contributes to growth and angiogenesis of glioblastoma. 2013, Pubmed
Hrstka, Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2. 2013, Pubmed
Hrstka, AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway. 2016, Pubmed
Hrstka, The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers. 2010, Pubmed
Innes, Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients. 2006, Pubmed
Inoue, An accurate and rapid detection of lymph node metastasis in non-small cell lung cancer patients based on one-step nucleic acid amplification assay. 2012, Pubmed
Ivanova, Agr genes, missing in amniotes, are involved in the body appendages regeneration in frog tadpoles. 2013, Pubmed , Xenbase
Jung, Basic helix-loop-helix transcription factor Twist1 is a novel regulator of anterior gradient protein 2 homolog (AGR2) in breast cancer. 2019, Pubmed
Kamal, High AGR2 protein is a feature of low grade endometrial cancer cells. 2018, Pubmed
Kani, Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. 2013, Pubmed
Kim, Genomic Network-Based Analysis Reveals Pancreatic Adenocarcinoma Up-Regulating Factor-Related Prognostic Markers in Cervical Carcinoma. 2018, Pubmed
Kim, Knockdown of anterior gradient 2 expression extenuates tumor-associated phenotypes of SNU-478 ampulla of Vater cancer cells. 2014, Pubmed
Kim, Expression of anterior gradient 2 is decreased with the progression of human biliary tract cancer. 2014, Pubmed
Kozlov, A structural overview of the PDI family of proteins. 2010, Pubmed
Lee, In vitro induction of anterior gradient-2-specific cytotoxic T lymphocytes by dendritic cells transduced with recombinant adenoviruses as a potential therapy for colorectal cancer. 2012, Pubmed
Li, The Role of HOX Transcription Factors in Cancer Predisposition and Progression. 2019, Pubmed
Li, AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer. 2019, Pubmed
Li, Binding of anterior gradient 2 and estrogen receptor-α: Dual critical roles in enhancing fulvestrant resistance and IGF-1-induced tumorigenesis of breast cancer. 2016, Pubmed
Li, Anterior gradient 2 is a binding stabilizer of hypoxia inducible factor-1α that enhances CoCl2 -induced doxorubicin resistance in breast cancer cells. 2015, Pubmed
Li, AGR2 diagnostic value in nasopharyngeal carcinoma prognosis. 2018, Pubmed
Linden, Mucins in the mucosal barrier to infection. 2008, Pubmed
Liu, Hydrogen peroxide mediated mitochondrial UNG1-PRDX3 interaction and UNG1 degradation. 2016, Pubmed
Liu, Knockdown of AGR2 induces cell apoptosis and reduces chemotherapy resistance of pancreatic cancer cells with the involvement of ERK/AKT axis. 2018, Pubmed
Liu, TP53 mediated miR-3647-5p prevents progression of cervical carcinoma by targeting AGR2. 2019, Pubmed
Liu, AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting. 2019, Pubmed
Ma, Anterior gradient protein 2 expression in high grade head and neck squamous cell carcinoma correlated with cancer stem cell and epithelial mesenchymal transition. 2015, Pubmed
Makawita, Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers. 2011, Pubmed
Martisova, AGR2 silencing contributes to metformin-dependent sensitization of colorectal cancer cells to chemotherapy. 2019, Pubmed
Maurel, Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation. 2019, Pubmed
Milewski, FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. 2017, Pubmed
Naxerova, Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers. 2008, Pubmed
Negi, Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study. 2019, Pubmed
Norris, AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia. 2013, Pubmed
Pan, miR-217 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitors by targeting pro-oncogenic anterior gradient 2. 2018, Pubmed
Park, The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. 2009, Pubmed
Park, AGR2, a mucinous ovarian cancer marker, promotes cell proliferation and migration. 2011, Pubmed
Patel, Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion. 2013, Pubmed
Persson, Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family. 2005, Pubmed
Petek, Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation. 2000, Pubmed , Xenbase
Pizzi, Anterior gradient 2 overexpression in lung adenocarcinoma. 2012, Pubmed
Pohler, The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage. 2004, Pubmed , Xenbase
Ramachandran, Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival. 2008, Pubmed
Rice, Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer. 2010, Pubmed
Riener, Loss of anterior gradient-2 expression is an independent prognostic factor in colorectal carcinomas. 2014, Pubmed
Ryu, Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78. 2013, Pubmed
Salmans, The estrogen-regulated anterior gradient 2 (AGR2) protein in breast cancer: a potential drug target and biomarker. 2013, Pubmed
Schroeder, AGR2 is induced in asthma and promotes allergen-induced mucin overproduction. 2012, Pubmed
Shi, A highly sensitive targeted mass spectrometric assay for quantification of AGR2 protein in human urine and serum. 2014, Pubmed
Shih, Characterization of the agr2 gene, a homologue of X. laevis anterior gradient 2, from the zebrafish, Danio rerio. 2007, Pubmed , Xenbase
Sive, A sticky problem: the Xenopus cement gland as a paradigm for anteroposterior patterning. 1996, Pubmed , Xenbase
Smirnov, Global gene expression profiling of circulating tumor cells. 2005, Pubmed
Sommerova, Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition. 2017, Pubmed
Sweeny, CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma. 2012, Pubmed
Tereshina, Agr2-interacting Prod1-like protein Tfp4 from Xenopus laevis is necessary for early forebrain and eye development as well as for the tadpole appendage regeneration. 2019, Pubmed , Xenbase
Thompson, hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. 1998, Pubmed , Xenbase
Tian, The prognostic value of AGR2 expression in solid tumours: a systematic review and meta-analysis. 2017, Pubmed
Tiemann, Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. 2019, Pubmed
Tohti, Serum AGR2 as a useful biomarker for pituitary adenomas. 2017, Pubmed
Tu, MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis. 2016, Pubmed
Vanderlaag, Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin. 2010, Pubmed
Verma, The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development. 2012, Pubmed
Vitello, Cancer-secreted AGR2 induces programmed cell death in normal cells. 2016, Pubmed
Vivekanandan, Anterior gradient-2 is overexpressed by fibrolamellar carcinomas. 2009, Pubmed
Wang, The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. 2008, Pubmed
Wayner, Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine. 2012, Pubmed
Whitwell, Improved early detection of ovarian cancer using longitudinal multimarker models. 2020, Pubmed
Wodziak, Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration. 2016, Pubmed
Wright, Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. 2014, Pubmed
Wu, [Preparation, characterization and potential application of monoclonal antibody 18A4 against AGR2]. 2010, Pubmed , Xenbase
Xiu, LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. 2019, Pubmed
Xu, The involvement of anterior gradient 2 in the stromal cell-derived factor 1-induced epithelial-mesenchymal transition of glioblastoma. 2016, Pubmed
Yosudjai, An aberrantly spliced isoform of anterior gradient-2, AGR2vH promotes migration and invasion of cholangiocarcinoma cell. 2018, Pubmed
Zhang, AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. 2005, Pubmed , Xenbase
Zhang, ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer. 2010, Pubmed
Zhang, AGR2 is associated with gastric cancer progression and poor survival. 2016, Pubmed
Zhu, Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain. 2017, Pubmed