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Dev Growth Differ
1991 Aug 01;334:299-306. doi: 10.1111/j.1440-169X.1991.00299.x.
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Contribution of VentralBlood Island (VBI)-Derived Cells to Postembryonic Liver Erythropoiesis in Xenopus laevis: (erythropoiesis/larval hemoglobin/liver/anemia/Xenopus).
Ohinata H
,
Enami T
.
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The ventralblood islands (VBI) of Xenopus laevis embryos are known as the hemopoietic site where the initial erythropoiesis takes place at st. 28. To determine the site of postembryonic erythropoiesis, larvae were induced anemic by phenylhydrazine (PHZ) at st. 31 and 40, and the tissue distribution of regenerating erythrocytes was determined with an anti-larval hemoglobin (LHb) monoclonal antibody. Three days after total anemia induction, the LHb+ cells were detected first in the liver and the digestive tract, followed by the appearance of a few LHb+ cells in the blood vessels. The lavae which had been hepatectomized and cardiectomized before the PHZ treatment showed a remarkable reduction in recovery of the LHb+ cells. Induction of anemia in the chimeric individuals containing cytogenetically labelled VBI tissues demonstrated that the VBI-derived cells contribute to the regenerating LHb+ cells in all experimental individuals. These results suggest that the larval liver is the major site where the VBI-derived hemopoietic cells reside and differentiate into erythrocytes.
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