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BMC Evol Biol
2009 Jan 15;9:12. doi: 10.1186/1471-2148-9-12.
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Dynamic evolution of bitter taste receptor genes in vertebrates.
Dong D
,
Jones G
,
Zhang S
.
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BACKGROUND: Sensing bitter tastes is crucial for many animals because it can prevent them from ingesting harmful foods. This process is mainly mediated by the bitter taste receptors (T2R), which are largely expressed in the taste buds. Previous studies have identified some T2R gene repertoires, and marked variation in repertoire size has been noted among species. However, the mechanisms underlying the evolution of vertebrate T2R genes remain poorly understood.
RESULTS: To better understand the evolutionary pattern of these genes, we identified 16 T2R gene repertoires based on the high coverage genome sequences of vertebrates and studied the evolutionary changes in the number of T2R genes during birth-and-death evolution using the reconciled-tree method. We found that the number of T2R genes and the fraction of pseudogenes vary extensively among species. Based on the results of phylogenetic analysis, we showed that T2R gene families in teleost fishes are more diverse than those in tetrapods. In addition to the independent gene expansions in teleost fishes, frogs and mammals, lineage-specific gene duplications were also detected in lizards. Furthermore, extensive gains and losses of T2R genes were detected in each lineage during their evolution, resulting in widely differing T2R gene repertoires.
CONCLUSION: These results further support the hypotheses that T2R gene repertoires are closely related to the dietary habits of different species and that birth-and-death evolution is associated with adaptations to dietary changes.
Adler,
A novel family of mammalian taste receptors.
2000, Pubmed
Adler,
A novel family of mammalian taste receptors.
2000,
Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Bufe,
The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.
2002,
Pubmed
Chandrashekar,
T2Rs function as bitter taste receptors.
2000,
Pubmed
Conte,
Identification and characterization of human taste receptor genes belonging to the TAS2R family.
2002,
Pubmed
Conte,
Evolutionary relationships of the Tas2r receptor gene families in mouse and human.
2003,
Pubmed
Fischer,
Evolution of bitter taste receptors in humans and apes.
2005,
Pubmed
Fredriksson,
The repertoire of G-protein-coupled receptors in fully sequenced genomes.
2005,
Pubmed
Gibbs,
Evolutionary and biomedical insights from the rhesus macaque genome.
2007,
Pubmed
Gibbs,
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
2004,
Pubmed
Glazko,
Estimation of divergence times for major lineages of primate species.
2003,
Pubmed
Glendinning,
Is the bitter rejection response always adaptive?
1994,
Pubmed
Glendinning,
Contribution of different bitter-sensitive taste cells to feeding inhibition in a caterpillar (Manduca sexta).
1999,
Pubmed
Gloriam,
The G protein-coupled receptor subset of the rat genome.
2007,
Pubmed
Go,
Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
2005,
Pubmed
Go,
Proceedings of the SMBE Tri-National Young Investigators' Workshop 2005. Lineage-specific expansions and contractions of the bitter taste receptor gene repertoire in vertebrates.
2006,
Pubmed
,
Xenbase
Grus,
Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.
2005,
Pubmed
Hedges,
The origin and evolution of model organisms.
2002,
Pubmed
Janke,
The complete mitochondrial genome of Alligator mississippiensis and the separation between recent archosauria (birds and crocodiles).
1997,
Pubmed
Katoh,
MAFFT version 5: improvement in accuracy of multiple sequence alignment.
2005,
Pubmed
Kumar,
MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.
2004,
Pubmed
Lagerström,
The G protein-coupled receptor subset of the chicken genome.
2006,
Pubmed
Lindblad-Toh,
Genome sequence, comparative analysis and haplotype structure of the domestic dog.
2005,
Pubmed
Manger,
Ultrastructure, number, distribution and innervation of electroreceptors and mechanoreceptors in the bill skin of the platypus, Ornithorhynchus anatinus.
1996,
Pubmed
Matsunami,
A family of candidate taste receptors in human and mouse.
2000,
Pubmed
Murphy,
Mammalian phylogenomics comes of age.
2004,
Pubmed
Nam,
Evolutionary change of the numbers of homeobox genes in bilateral animals.
2005,
Pubmed
Nelson,
An amino-acid taste receptor.
2002,
Pubmed
Niimura,
Extensive gains and losses of olfactory receptor genes in mammalian evolution.
2007,
Pubmed
Nishihara,
Pegasoferae, an unexpected mammalian clade revealed by tracking ancient retroposon insertions.
2006,
Pubmed
Page,
From gene to organismal phylogeny: reconciled trees and the gene tree/species tree problem.
1997,
Pubmed
Page,
Vertebrate phylogenomics: reconciled trees and gene duplications.
2002,
Pubmed
Parry,
Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees.
2004,
Pubmed
Pontius,
Initial sequence and comparative analysis of the cat genome.
2007,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Shi,
Adaptive diversification of bitter taste receptor genes in Mammalian evolution.
2003,
Pubmed
Shi,
Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes.
2006,
Pubmed
Striem,
Sweet tastants stimulate adenylate cyclase coupled to GTP-binding protein in rat tongue membranes.
1989,
Pubmed
Teeter,
Amino acid receptor channels in taste cells.
1992,
Pubmed
Waddell,
A phylogenetic foundation for comparative mammalian genomics.
2001,
Pubmed
Wang,
Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes.
2004,
Pubmed
Warren,
Genome analysis of the platypus reveals unique signatures of evolution.
2008,
Pubmed
Wong,
Transduction of bitter and sweet taste by gustducin.
1996,
Pubmed
Zhang,
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
2003,
Pubmed
