Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Environ Sci Ecotechnol
2022 Jul 01;11:100185. doi: 10.1016/j.ese.2022.100185.
Show Gene links
Show Anatomy links
Gut microbiota dysbiosis involves in host non-alcoholic fatty liver disease upon pyrethroid pesticide exposure.
Li M
,
Liu T
,
Yang T
,
Zhu J
,
Zhou Y
,
Wang M
,
Wang Q
.
???displayArticle.abstract???
A growing body of evidence has demonstrated the significance of the gut microbiota in host health, while the association between gut microbiota dysbiosis and multiple diseases is yet elusive in the scenario of exposure to widely used pesticides. Here, we show that gut microbiota dysbiosis involves in host's abnormal lipid metabolism and consequently the non-alcoholic fatty liver disease in Xenopus laevis upon exposure to cis-bifenthrin, one of the most prevalent pyrethroid insecticides in the world. With the guidance of gut microbiota analysis, we found that cis-bifenthrin exposure significantly perturbed the gut microbial community, and the specific taxa that served as biomarkers were identified. Metabolomics profiling and association analysis further showed that a significant change of intestinal metabolites involved in lipid metabolic pathways were induced along with the microbiota dysbiosis upon exposure to cis-bifenthrin. Detailed investigation showed an altered functional regulation of lipids in the liver after cis-bifenthrin exposure and the accumulation of lipid droplets in hepatocytes. Specifically, a change in deoxycholic acid alters bile acid hepatoenteral circulation, which affects lipid metabolism in the liver and ultimately causes the development of fatty liver disease. Collectively, these findings provide novel insight into the gut microbiota dysbiosis upon pesticide exposure and their potential implication in the development of chronic host diseases related to liver metabolic syndrome.
Ba,
Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice.
2017, Pubmed
Ba,
Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice.
2017,
Pubmed
Bertotto,
Effects of bifenthrin exposure on the estrogenic and dopaminergic pathways in zebrafish embryos and juveniles.
2018,
Pubmed
Chiang,
Bile acid metabolism and signaling.
2013,
Pubmed
Chiang,
Bile acid metabolism and signaling in liver disease and therapy.
2017,
Pubmed
Chu,
Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease.
2019,
Pubmed
Claus,
The gut microbiota: a major player in the toxicity of environmental pollutants?
2016,
Pubmed
Corcellas,
First report of pyrethroid bioaccumulation in wild river fish: a case study in Iberian river basins (Spain).
2015,
Pubmed
Cuevas-Sierra,
Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications.
2019,
Pubmed
Dabke,
The gut microbiome and metabolic syndrome.
2019,
Pubmed
Dada,
Pyrethroid exposure alters internal and cuticle surface bacterial communities in Anopheles albimanus.
2019,
Pubmed
Delgado-Moreno,
Occurrence and toxicity of three classes of insecticides in water and sediment in two Southern California coastal watersheds.
2011,
Pubmed
Doden,
Completion of the gut microbial epi-bile acid pathway.
2021,
Pubmed
Evariste,
Thermal Reduction of Graphene Oxide Mitigates Its In Vivo Genotoxicity Toward Xenopus laevis Tadpoles.
2019,
Pubmed
,
Xenbase
Fanale,
The Interplay between Metabolism, PPAR Signaling Pathway, and Cancer.
2017,
Pubmed
Farina,
Deoxycholic acid in the submental fat reduction: A review of properties, adverse effects, and complications.
2020,
Pubmed
Fernández-Bravo,
An Update on the Genus Aeromonas: Taxonomy, Epidemiology, and Pathogenicity.
2020,
Pubmed
Gao,
Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions.
2017,
Pubmed
Gao,
The Carbamate Aldicarb Altered the Gut Microbiome, Metabolome, and Lipidome of C57BL/6J Mice.
2019,
Pubmed
He,
Occurrence, sources, and ecological risks of three classes of insecticides in sediments of the Liaohe River basin, China.
2021,
Pubmed
Hu,
Effects of environmental pyrethroids exposure on semen quality in reproductive-age men in Shanghai, China.
2020,
Pubmed
Just,
The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism.
2018,
Pubmed
Kaakoush,
Insights into the Role of Erysipelotrichaceae in the Human Host.
2015,
Pubmed
Li,
Effect of titanium dioxide nanoparticles on the bioavailability and neurotoxicity of cypermethrin in zebrafish larvae.
2018,
Pubmed
Li,
Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis.
2020,
Pubmed
,
Xenbase
Magnuson,
Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment.
2020,
Pubmed
Martínez,
Diet-induced alterations of host cholesterol metabolism are likely to affect the gut microbiota composition in hamsters.
2013,
Pubmed
Mosca,
Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
2016,
Pubmed
Nasuti,
Changes on fecal microbiota in rats exposed to permethrin during postnatal development.
2016,
Pubmed
Pineda Torra,
Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
2003,
Pubmed
Pérez-Alvarez,
Determination of metals and pharmaceutical compounds released in hospital wastewater from Toluca, Mexico, and evaluation of their toxic impact.
2018,
Pubmed
,
Xenbase
Ramírez-Pérez,
The Role of the Gut Microbiota in Bile Acid Metabolism.
2017,
Pubmed
Ravula,
Effect of oral administration of a mixture of pyrethroids at doses relevant to human exposure on the general and male reproductive physiology in the rat.
2021,
Pubmed
Ridlon,
Bile acids and the gut microbiome.
2014,
Pubmed
Ridlon,
Consequences of bile salt biotransformations by intestinal bacteria.
2016,
Pubmed
Saillenfait,
Pyrethroids: exposure and health effects--an update.
2015,
Pubmed
Seebacher,
Hepatic lipid droplet homeostasis and fatty liver disease.
2020,
Pubmed
Sinha,
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
2020,
Pubmed
Suchodolski,
Diagnosis and interpretation of intestinal dysbiosis in dogs and cats.
2016,
Pubmed
Tang,
Pyrethroid pesticide residues in the global environment: An overview.
2018,
Pubmed
Ursell,
The intestinal metabolome: an intersection between microbiota and host.
2014,
Pubmed
Vital,
Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut.
2019,
Pubmed
Wang,
Gut Microbiota Dysbiosis Is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis.
2019,
Pubmed
Wang,
Molecular characterization and different expression patterns of the FABP gene family during goat skeletal muscle development.
2015,
Pubmed
Wu,
Chronic exposure to fungicide propamocarb induces bile acid metabolic disorder and increases trimethylamine in C57BL/6J mice.
2018,
Pubmed
Xiang,
Chronic exposure to environmental levels of cis-bifenthrin: Enantioselectivity and reproductive effects on zebrafish (Danio rerio).
2019,
Pubmed
Yang,
Cadmium potentiates toxicity of cypermethrin in zebrafish.
2016,
Pubmed
Zhang,
Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation.
2015,
Pubmed
Zhou,
Environmental concentrations of antibiotics impair zebrafish gut health.
2018,
Pubmed
Álvarez-Nava,
PPARGC1A promoter DNA-methylation level and glucose metabolism in Ecuadorian women with Turner syndrome.
2020,
Pubmed