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Molecules
2021 Dec 31;271:. doi: 10.3390/molecules27010249.
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Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in Xenopus laevis.
Dong M
,
Li Y
,
Zhu M
,
Li J
,
Qin Z
.
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Although tetrabromobisphenol A (TBBPA) has been well proven to disturb TH signaling in both in vitro and in vivo assays, it is still unclear whether TBBPA can affect brain development due to TH signaling disruption. Here, we employed the T3-induced Xenopus metamorphosis assay (TIXMA) and the spontaneous metamorphosis assay to address this issue. In the TIXMA, 5-500 nmol/L TBBPA affected T3-induced TH-response gene expression and T3-induced brain development (brain morphological changes, cell proliferation, and neurodifferentiation) at premetamorphic stages in a complicated biphasic concentration-response manner. Notably, 500 nmol/L TBBPA treatment alone exerted a stimulatory effect on tadpole growth and brain development at these stages, in parallel with a lack of TH signaling activation, suggesting the involvement of other signaling pathways. As expected, at the metamorphic climax, we observed inhibitory effects of 50-500 nmol/L TBBPA on metamorphic development and brain development, which was in agreement with the antagonistic effects of higher concentrations on T3-induced brain development at premetamorphic stages. Taken together, all results demonstrate that TBBPA can disturb TH signaling and subsequently interfere with TH-dependent brain development in Xenopus; meanwhile, other signaling pathways besides TH signaling could be involved in this process. Our study improves the understanding of the effects of TBBPA on vertebrate brain development.
2018YFA0901103 National the Key Research and Development Program of China, 21876196 the National Natural Science Foundation of China, XDB14040102 the Strategic Priority Research Program of the Chinese Academy of Sciences
Cai,
Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization.
2020, Pubmed,
Xenbase
Cai,
Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization.
2020,
Pubmed
,
Xenbase
Cariou,
Exposure assessment of French women and their newborns to tetrabromobisphenol-A: occurrence measurements in maternal adipose tissue, serum, breast milk and cord serum.
2008,
Pubmed
Chen,
TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish.
2016,
Pubmed
Crump,
Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.
2002,
Pubmed
,
Xenbase
D'Amico,
Proliferation, migration and differentiation in juvenile and adult Xenopus laevis brains.
2011,
Pubmed
,
Xenbase
Dong,
Tetrabromobisphenol A: a neurotoxicant or not?
2021,
Pubmed
Fini,
Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption.
2012,
Pubmed
,
Xenbase
Fini,
Parallel biotransformation of tetrabromobisphenol A in Xenopus laevis and mammals: Xenopus as a model for endocrine perturbation studies.
2012,
Pubmed
,
Xenbase
Gunderson,
Effect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana).
2011,
Pubmed
Hakk,
Metabolism in the toxicokinetics and fate of brominated flame retardants--a review.
2003,
Pubmed
Hogan,
Hormone cross-regulation in the tadpole brain: developmental expression profiles and effect of T3 exposure on thyroid hormone- and estrogen-responsive genes in Rana pipiens.
2007,
Pubmed
Horn,
Thyroid hormone action during brain development: more questions than answers.
2010,
Pubmed
Kacew,
Absence of neurotoxicity and lack of neurobehavioral consequences due to exposure to tetrabromobisphenol A (TBBPA) exposure in humans, animals and zebrafish.
2020,
Pubmed
Kitamura,
Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.
2005,
Pubmed
Li,
Serum concentration of bisphenol analogues in pregnant women in China.
2020,
Pubmed
Liang,
Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling.
2019,
Pubmed
Liu,
Pharmacokinetics and effects of tetrabromobisphenol a (TBBPA) to early life stages of zebrafish (Danio rerio).
2018,
Pubmed
Livak,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
2001,
Pubmed
Lu,
Thyroid Disruption by Bisphenol S Analogues via Thyroid Hormone Receptor β: in Vitro, in Vivo, and Molecular Dynamics Simulation Study.
2018,
Pubmed
Malkoske,
A review of the environmental distribution, fate, and control of tetrabromobisphenol A released from sources.
2016,
Pubmed
Mengeling,
A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.
2017,
Pubmed
,
Xenbase
Morvan-Dubois,
Xenopus laevis as a model for studying thyroid hormone signalling: from development to metamorphosis.
2008,
Pubmed
,
Xenbase
Niu,
Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis.
2021,
Pubmed
,
Xenbase
Rovet,
The role of thyroid hormones for brain development and cognitive function.
2014,
Pubmed
Shi,
Levels of tetrabromobisphenol A, hexabromocyclododecanes and polybrominated diphenyl ethers in human milk from the general population in Beijing, China.
2013,
Pubmed
Shi,
Tadpole competence and tissue-specific temporal regulation of amphibian metamorphosis: roles of thyroid hormone and its receptors.
1996,
Pubmed
,
Xenbase
Shi,
Cloning and characterization of the ribosomal protein L8 gene from Xenopus laevis.
1994,
Pubmed
,
Xenbase
Sun,
Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay.
2009,
Pubmed
Tata,
Amphibian metamorphosis as a model for the developmental actions of thyroid hormone.
2006,
Pubmed
,
Xenbase
Wang,
Re-evaluation of thyroid hormone signaling antagonism of tetrabromobisphenol A for validating the T3-induced Xenopus metamorphosis assay.
2017,
Pubmed
,
Xenbase
Wong,
Coordinated regulation of and transcriptional activation by Xenopus thyroid hormone and retinoid X receptors.
1995,
Pubmed
,
Xenbase
Yang,
Tetrabromobisphenol A: tissue distribution in fish, and seasonal variation in water and sediment of Lake Chaohu, China.
2012,
Pubmed
Yao,
Optimization of the T3-induced Xenopus metamorphosis assay for detecting thyroid hormone signaling disruption of chemicals.
2017,
Pubmed
,
Xenbase
Yin,
TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways.
2018,
Pubmed
Yu,
Tetrabromobisphenol A: Disposition, kinetics and toxicity in animals and humans.
2019,
Pubmed
Zhang,
Tetrabromobisphenol A disrupts vertebrate development via thyroid hormone signaling pathway in a developmental stage-dependent manner.
2014,
Pubmed
,
Xenbase
Zhang,
Notch: an interactive player in neurogenesis and disease.
2018,
Pubmed
Zhu,
Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis.
2018,
Pubmed
,
Xenbase