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Biophys J
2006 Jun 01;9011:3897-907. doi: 10.1529/biophysj.105.075911.
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Analysis of puff dynamics in oocytes: interdependence of puff amplitude and interpuff interval.
Fraiman D
,
Pando B
,
Dargan S
,
Parker I
,
Dawson SP
.
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Puffs are localized Ca(2+) signals that arise in oocytes in response to inositol 1,4,5-trisphosphate (IP(3)). They are analogous to the sparks of myocytes and are believed to be the result of the liberation of Ca(2+) from the endoplasmic reticulum through the coordinated opening of IP(3) receptor/channels clustered at a functional release site. In this article, we analyze sequences of puffs that occur at the same site to help elucidate the mechanisms underlying puff dynamics. In particular, we show a dependence of the interpuff time on the amplitude of the preceding puff, and of the amplitude of the following puff on the preceding interval. These relationships can be accounted for by an inhibitory role of the Ca(2+) that is liberated during puffs. We construct a stochastic model for a cluster of IP(3) receptor/channels that quantitatively replicates the observed behavior, and we determine that the characteristic time for a channel to escape from the inhibitory state is of the order of seconds.
Adkins,
Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca(2+).
1999, Pubmed
Adkins,
Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca(2+).
1999,
Pubmed
Bezprozvanny,
Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum.
1991,
Pubmed
Bezprozvanny,
Inositol (1,4,5)-trisphosphate (InsP3)-gated Ca channels from cerebellum: conduction properties for divalent cations and regulation by intraluminal calcium.
1994,
Pubmed
Callamaras,
Phasic characteristic of elementary Ca(2+) release sites underlies quantal responses to IP(3).
2000,
Pubmed
,
Xenbase
Dargan,
Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals.
2003,
Pubmed
,
Xenbase
De Young,
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
1992,
Pubmed
Finch,
Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release.
1991,
Pubmed
Fraiman,
A model of IP3 receptor with a luminal calcium binding site: stochastic simulations and analysis.
2004,
Pubmed
Hüser,
Elementary events of agonist-induced Ca2+ release in vascular endothelial cells.
1997,
Pubmed
Iino,
Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci.
1990,
Pubmed
Koizumi,
Characterization of elementary Ca2+ release signals in NGF-differentiated PC12 cells and hippocampal neurons.
1999,
Pubmed
Mak,
ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells.
2001,
Pubmed
,
Xenbase
Mak,
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.
1998,
Pubmed
,
Xenbase
Marchant,
Rapid activation and partial inactivation of inositol trisphosphate receptors by inositol trisphosphate.
1998,
Pubmed
Melamed-Book,
Neuronal calcium sparks and intracellular calcium "noise".
1999,
Pubmed
,
Xenbase
Nguyen,
Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+.
1998,
Pubmed
Parker,
Inhibition by Ca2+ of inositol trisphosphate-mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+.
1990,
Pubmed
,
Xenbase
Parker,
Characteristics of membrane currents evoked by photoreleased inositol trisphosphate in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Parker,
A high-resolution, confocal laser-scanning microscope and flash photolysis system for physiological studies.
1997,
Pubmed
,
Xenbase
Ramos-Franco,
Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels.
1998,
Pubmed
Shuai,
Optical single-channel recording by imaging Ca2+ flux through individual ion channels: theoretical considerations and limits to resolution.
2005,
Pubmed
,
Xenbase
Sun,
A continuum of InsP3-mediated elementary Ca2+ signalling events in Xenopus oocytes.
1998,
Pubmed
,
Xenbase
Swillens,
From calcium blips to calcium puffs: theoretical analysis of the requirements for interchannel communication.
1999,
Pubmed
,
Xenbase
Szentesi,
Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle.
2004,
Pubmed
Terentyev,
Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes.
2002,
Pubmed
Thomas,
Microscopic properties of elementary Ca2+ release sites in non-excitable cells.
2000,
Pubmed
Thul,
Release currents of IP(3) receptor channel clusters and concentration profiles.
2004,
Pubmed
,
Xenbase
Ventura,
A model-independent algorithm to derive Ca2+ fluxes underlying local cytosolic Ca2+ transients.
2005,
Pubmed
,
Xenbase
Yao,
Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
