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Philos Trans R Soc Lond B Biol Sci
2020 Oct 12;3751809:20190564. doi: 10.1098/rstb.2019.0564.
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On folding morphogenesis, a mechanical problem.
Tozluoǧlu M
,
Mao Y
.
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Tissue folding is a fundamental process that sculpts a simple flat epithelium into a complex three-dimensional organ structure. Whether it is the folding of the brain, or the looping of the gut, it has become clear that to generate an invagination or a fold of any form, mechanical asymmetries must exist in the epithelium. These mechanical asymmetries can be generated locally, involving just the invaginating cells and their immediate neighbours, or on a more global tissue-wide scale. Here, we review the different mechanical mechanisms that epithelia have adopted to generate folds, and how the use of precisely defined mathematical models has helped decipher which mechanisms are the key driving forces in different epithelia. This article is part of a discussion meeting issue 'Contemporary morphogenesis'.
Bogdanović,
Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis.
2012,
Pubmed
Booth,
A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation.
2014,
Pubmed
Borrell,
How Cells Fold the Cerebral Cortex.
2018,
Pubmed
Brodu,
The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination.
2006,
Pubmed
Budday,
A mechanical model predicts morphological abnormalities in the developing human brain.
2014,
Pubmed
Chung,
Uncoupling apical constriction from tissue invagination.
2017,
Pubmed
Conte,
A 3D finite element model of ventral furrow invagination in the Drosophila melanogaster embryo.
2008,
Pubmed
Conte,
A biomechanical analysis of ventral furrow formation in the Drosophila melanogaster embryo.
2012,
Pubmed
Davidson,
Epithelial machines that shape the embryo.
2012,
Pubmed
,
Xenbase
Dawes-Hoang,
folded gastrulation, cell shape change and the control of myosin localization.
2005,
Pubmed
Dervaux,
Morphogenesis of growing soft tissues.
2008,
Pubmed
Ghabrial,
Branching morphogenesis of the Drosophila tracheal system.
2003,
Pubmed
Gjorevski,
Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture.
2017,
Pubmed
Granholm,
Cytoplasmic microtubules and the mechanism of avian gastrulation.
1970,
Pubmed
Gutzman,
Formation of the zebrafish midbrain-hindbrain boundary constriction requires laminin-dependent basal constriction.
2008,
Pubmed
Gutzman,
Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase.
2018,
Pubmed
Gutzman,
Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis.
2015,
Pubmed
He,
Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation.
2014,
Pubmed
Heer,
Actomyosin-based tissue folding requires a multicellular myosin gradient.
2017,
Pubmed
Heer,
Tension, contraction and tissue morphogenesis.
2017,
Pubmed
Hruban,
Progression model for pancreatic cancer.
2000,
Pubmed
Hughes,
Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.
2018,
Pubmed
Kim,
Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung.
2015,
Pubmed
Kondo,
Mitotic cell rounding accelerates epithelial invagination.
2013,
Pubmed
Kondo,
Mechanisms of cell height changes that mediate epithelial invagination.
2015,
Pubmed
Kölsch,
Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.
2007,
Pubmed
LEWIS,
Mechanics of invagination.
1947,
Pubmed
Lee,
Shaping of a three-dimensional carnivorous trap through modulation of a planar growth mechanism.
2019,
Pubmed
Lejeune,
Understanding the mechanical link between oriented cell division and cerebellar morphogenesis.
2019,
Pubmed
Leptin,
Drosophila gastrulation: from pattern formation to morphogenesis.
1995,
Pubmed
Liang,
The shape of a long leaf.
2009,
Pubmed
Manjón,
Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis.
2007,
Pubmed
Mao,
Differential proliferation rates generate patterns of mechanical tension that orient tissue growth.
2013,
Pubmed
Martin,
Pulsed contractions of an actin-myosin network drive apical constriction.
2009,
Pubmed
Martin,
Integration of contractile forces during tissue invagination.
2010,
Pubmed
Martinez-Morales,
ojoplano-mediated basal constriction is essential for optic cup morphogenesis.
2009,
Pubmed
Messal,
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
2019,
Pubmed
Metzger,
The branching programme of mouse lung development.
2008,
Pubmed
Meyer,
Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia.
2011,
Pubmed
Monier,
Apico-basal forces exerted by apoptotic cells drive epithelium folding.
2015,
Pubmed
Mota,
BRAIN STRUCTURE. Cortical folding scales universally with surface area and thickness, not number of neurons.
2015,
Pubmed
Neal,
Insights into the gyrification of developing ferret brain by magnetic resonance imaging.
2007,
Pubmed
Nicolás-Pérez,
Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis.
2016,
Pubmed
Nishimura,
A wave of EGFR signaling determines cell alignment and intercalation in the Drosophila tracheal placode.
2007,
Pubmed
Pearl,
Cellular systems for epithelial invagination.
2017,
Pubmed
Polyakov,
Passive mechanical forces control cell-shape change during Drosophila ventral furrow formation.
2014,
Pubmed
Rebocho,
Generation of shape complexity through tissue conflict resolution.
2017,
Pubmed
Röper,
Supracellular actomyosin assemblies during development.
2013,
Pubmed
Röper,
Anisotropy of Crumbs and aPKC drives myosin cable assembly during tube formation.
2012,
Pubmed
Savin,
On the growth and form of the gut.
2011,
Pubmed
Seher,
Analysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo.
2007,
Pubmed
Shyer,
Villification: how the gut gets its villi.
2013,
Pubmed
,
Xenbase
Sidhaye,
Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis.
2017,
Pubmed
Sui,
Differential lateral and basal tension drive folding of Drosophila wing discs through two distinct mechanisms.
2018,
Pubmed
Sui,
The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc.
2012,
Pubmed
Takeda,
A homeostatic apical microtubule network shortens cells for epithelial folding via a basal polarity shift.
2018,
Pubmed
Tallinen,
Gyrification from constrained cortical expansion.
2014,
Pubmed
Tozluoǧlu,
Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia.
2019,
Pubmed
Varner,
Mechanically patterning the embryonic airway epithelium.
2015,
Pubmed
Visetsouk,
Basal epithelial tissue folding is mediated by differential regulation of microtubules.
2018,
Pubmed
Wang,
Differential positioning of adherens junctions is associated with initiation of epithelial folding.
2012,
Pubmed
Wang,
Complementary expression of optomotor-blind and the Iroquois complex promotes fold formation to separate wing notum and hinge territories.
2016,
Pubmed
Willige,
D6PK AGCVIII kinases are required for auxin transport and phototropic hypocotyl bending in Arabidopsis.
2013,
Pubmed
Xu,
Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase.
2008,
Pubmed
Yevick,
Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding.
2019,
Pubmed