Lewis A , McCrossan ZA , Manville RW , Popa MO , Cuello LG , Goldstein SAN .

R01 NS058505 NINDS NIH HHS , R01 GM097159 NIGMS NIH HHS , R01 GM111716 NIGMS NIH HHS , BB/J006114/1 Biotechnology and Biological Sciences Research Council , R01 GM054237 NIGMS NIH HHS , R01 HL061657 NHLBI NIH HHS

Ahmed, A molecular target for viral killer toxin: TOK1 potassium channels. 1999, Pubmed, Xenbase

Ahmed, A molecular target for viral killer toxin: TOK1 potassium channels. 1999, Pubmed , Xenbase
Ando, Coupled K+-water flux through the HERG potassium channel measured by an osmotic pulse method. 2005, Pubmed
Aryal, A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. 2014, Pubmed , Xenbase
Baev, Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1. 2003, Pubmed
Bagriantsev, Multiple modalities converge on a common gate to control K2P channel function. 2011, Pubmed
Ben Soussia, Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels. 2019, Pubmed
Ben-Abu, Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling. 2009, Pubmed
Bernèche, A gate in the selectivity filter of potassium channels. 2005, Pubmed
Bertl, Physiological characterization of the yeast plasma membrane outward rectifying K+ channel, DUK1 (TOK1), in situ. 1998, Pubmed
Bichet, Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. 2006, Pubmed , Xenbase
Brettmann, Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel. 2015, Pubmed
Brohawn, Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. 2012, Pubmed
Brohawn, Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. 2013, Pubmed
Brown, Hidden killers: human fungal infections. 2012, Pubmed
Brown, A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating. 2008, Pubmed , Xenbase
Coonen, The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. 2020, Pubmed
Cuello, Structural mechanism of C-type inactivation in K(+) channels. 2010, Pubmed
Cuello, The gating cycle of a K+ channel at atomic resolution. 2017, Pubmed
Cuello, Structural basis for the coupling between activation and inactivation gates in K(+) channels. 2010, Pubmed
Demo, Ion effects on gating of the Ca(2+)-activated K+ channel correlate with occupancy of the pore. 1992, Pubmed
Dong, K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. 2015, Pubmed
Díaz-Franulic, Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels. 2015, Pubmed , Xenbase
Flynn, Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels. 2001, Pubmed , Xenbase
Goldstein, ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. 1996, Pubmed , Xenbase
Goldstein, Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. 1998, Pubmed
Guerrero-Galán, Plant potassium nutrition in ectomycorrhizal symbiosis: properties and roles of the three fungal TOK potassium channels in Hebeloma cylindrosporum. 2018, Pubmed
Heer, Mechanism of activation at the selectivity filter of the KcsA K+ channel. 2017, Pubmed
Iwamoto, Counting ion and water molecules in a streaming file through the open-filter structure of the K channel. 2011, Pubmed
Jensen, Atomic-level simulation of current-voltage relationships in single-file ion channels. 2013, Pubmed
Jia, Hydrophobic gating in BK channels. 2018, Pubmed
Jiang, The open pore conformation of potassium channels. 2002, Pubmed
Jiang, The barium site in a potassium channel by x-ray crystallography. 2000, Pubmed
Ketchum, A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. 1995, Pubmed , Xenbase
Kollewe, A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics. 2009, Pubmed
Köpfer, Ion permeation in K⁺ channels occurs by direct Coulomb knock-on. 2014, Pubmed
Labro, Inverted allosteric coupling between activation and inactivation gates in K+ channels. 2018, Pubmed
Lengyel, TRESK background potassium channel is not gated at the helix bundle crossing near the cytoplasmic end of the pore. 2018, Pubmed , Xenbase
Lesage, TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. 1996, Pubmed , Xenbase
Lesage, A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties. 1996, Pubmed , Xenbase
Li, Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel. 2018, Pubmed
Lolicato, Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels. 2014, Pubmed , Xenbase
Loukin, K(+)-dependent composite gating of the yeast K(+) channel, Tok1. 1999, Pubmed , Xenbase
Loukin, Random mutagenesis reveals a region important for gating of the yeast K+ channel Ykc1. 1997, Pubmed , Xenbase
Loukin, The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel. 2002, Pubmed
López-Barneo, Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. 1993, Pubmed , Xenbase
Ma, External Ba2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter. 2011, Pubmed , Xenbase
Maresova, Measurements of plasma membrane potential changes in Saccharomyces cerevisiae cells reveal the importance of the Tok1 channel in membrane potential maintenance. 2006, Pubmed
Matulef, Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels. 2013, Pubmed
Matulef, Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation. 2016, Pubmed
Miller, Coupling of water and ion fluxes in a K+-selective channel of sarcoplasmic reticulum. 1982, Pubmed
Morais-Cabral, Energetic optimization of ion conduction rate by the K+ selectivity filter. 2001, Pubmed
Nishida, Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. 2007, Pubmed
Pan, Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations. 2011, Pubmed
Piechotta, The pore structure and gating mechanism of K2P channels. 2011, Pubmed
Prole, Identification and analysis of cation channel homologues in human pathogenic fungi. 2012, Pubmed
Rajan, Sumoylation silences the plasma membrane leak K+ channel K2P1. 2005, Pubmed , Xenbase
Rapedius, State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. 2012, Pubmed , Xenbase
Roberts, TOK homologue in Neurospora crassa: first cloning and functional characterization of an ion channel in a filamentous fungus. 2003, Pubmed
Roller, Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p. 2008, Pubmed
Roller, In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance. 2005, Pubmed
Schewe, A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels. 2016, Pubmed
Sesti, Immunity to K1 killer toxin: internal TOK1 blockade. 2001, Pubmed
Shiraki, Cytokine secretion profiles of human keratinocytes during Trichophyton tonsurans and Arthroderma benhamiae infections. 2006, Pubmed
Squeo, Invasive Trichophyton rubrum resembling blastomycosis infection in the immunocompromised host. 1998, Pubmed
Thompson, Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. 2009, Pubmed
Tilegenova, Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion-bound configuration. 2019, Pubmed
Tsukamoto, Structural properties determining low K+ affinity of the selectivity filter in the TWIK1 K+ channel. 2018, Pubmed
Ye, Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. 2010, Pubmed
Yellen, The moving parts of voltage-gated ion channels. 1998, Pubmed
Zheng, Selectivity changes during activation of mutant Shaker potassium channels. 1997, Pubmed , Xenbase
Zhou, Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. 2001, Pubmed
Zhou, YKC1 encodes the depolarization-activated K+ channel in the plasma membrane of yeast. 1995, Pubmed
Zilberberg, KCNKØ: opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore. 2001, Pubmed , Xenbase