XB-ART-56295
Dev Cell
2009 Feb 01;162:165-6. doi: 10.1016/j.devcel.2009.01.017.
Show Gene links
Show Anatomy links
SUMO weighs in on a photoreceptor finish.
???displayArticle.abstract???
In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.
???displayArticle.pubmedLink??? 19217419
???displayArticle.link??? Dev Cell
???displayArticle.grants???
Species referenced: Xenopus
Genes referenced: nr2e3 pias3