XB-ART-5621
Trends Cell Biol
2003 Mar 01;133:110-3. doi: 10.1016/s0962-8924(03)00024-2.
Show Gene links
Show Anatomy links
Down to the origin: Cdc6 protein and the competence to replicate.
???displayArticle.abstract???
In eukaryotes, DNA replication requires the regulated assembly of pre-replicative complexes (pre-RCs) onto DNA during G1 phase. Pre-RCs render the chromatin competent to replicate, yet it is only at the G1-S phase transition that protein-kinase complexes trigger the transition to DNA replication. Central to the formation of pre-RCs and regulation of DNA replication is the Cdc6 protein. Two recent studies have shown that Cdc6 is the long-sought factor that confers the competence to replicate in unfertilized Xenopus eggs.
???displayArticle.pubmedLink??? 12628342
???displayArticle.link??? Trends Cell Biol
Species referenced: Xenopus
Genes referenced: cdc6