XB-ART-55996
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
2019 Aug 01;2054:567-582. doi: 10.1007/s00359-019-01351-3.
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The plus maze and scototaxis test are not valid behavioral assays for anxiety assessment in the South African clawed frog.
Coleman RB
,
Aguirre K
,
Spiegel HP
,
Pecos C
,
Carr JA
,
Harris BN
.
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There are no behavioral models for testing anxiety in amphibians, a group of animals widely used for developmental, ecotoxicological, and genetic research. We aimed to validate two common rodent paradigms, the plus maze and the scototaxis test, for use in the aquatic African clawed frog (Xenopus laevis). We predicted: (a) that frogs would prefer the dark, vs. light, portions of the testing arenas (face validity), (b) that this behavior could be altered with acute administration of anxio-selective drugs (construct validity), and (c) that time spent in the dark portions of the arenas would be positively correlated (predictive validity). Prior to testing, frogs were treated with fluoxetine (selective serotonin reuptake inhibitor [SSRI]), desipramine (serotonin- and norepinephrine-reuptake inhibitor), caffeine (methylxanthine, adenosine receptor antagonist, phosphodiesterase inhibitor), saline, or were left unmanipulated. Each drug was administered acutely (1 h prior to testing; caffeine) or subacutely (24, 3, and 1 h prior to testing; fluoxetine, desipramine) at one of three doses. Plus maze and scototaxis testing were separated by 1 week; each frog completed both behavioral tasks and was treated with the same drug regimen prior to testing. Overall, both tests showed face validity, however, data suggest these paradigms lack both construct and predictive validity.
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1035096 National Science Foundation, 1656734 National Science Foundation
References [+] :
Adhikari,
Distributed circuits underlying anxiety.
2014, Pubmed
Adhikari, Distributed circuits underlying anxiety. 2014, Pubmed
Anderzhanova, Animal models in psychiatric research: The RDoC system as a new framework for endophenotype-oriented translational neuroscience. 2017, Pubmed
Beaufour, Effects of chronic antidepressants in an operant conflict procedure of anxiety in the rat. 1999, Pubmed
Belzung, Measuring normal and pathological anxiety-like behaviour in mice: a review. 2001, Pubmed
Belzung, Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression. 2011, Pubmed
Benjamin, Redefine statistical significance. 2018, Pubmed
Berg, Developmental exposure to fluoxetine modulates the serotonin system in hypothalamus. 2013, Pubmed , Xenbase
Blanchard, The role of behavior in translational models for psychopathology: functionality and dysfunctional behaviors. 2013, Pubmed
Blaser, Behavioral measures of anxiety in zebrafish (Danio rerio). 2010, Pubmed
Blaser, Measures of anxiety in zebrafish (Danio rerio): dissociation of black/white preference and novel tank test. 2012, Pubmed
Borsini, Do animal models of anxiety predict anxiolytic-like effects of antidepressants? 2002, Pubmed
Bourin, The mouse light/dark box test. 2003, Pubmed
Brodin, Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations. 2013, Pubmed
Brooks, Fish on Prozac (and Zoloft): ten years later. 2014, Pubmed
Carhart-Harris, Psychedelics and the essential importance of context. 2018, Pubmed
Carobrez, Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. 2005, Pubmed
Carr, Response of larval Xenopus laevis to atrazine: assessment of growth, metamorphosis, and gonadal and laryngeal morphology. 2003, Pubmed , Xenbase
Carr, I'll take the low road: the evolutionary underpinnings of visually triggered fear. 2015, Pubmed
Charney, Serotonin function and mechanism of action of antidepressant treatment. Effects of amitriptyline and desipramine. 1984, Pubmed
Clinchy, The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another. 2010, Pubmed
Correa, Is there a major role for adenosine A2A receptors in anxiety? 2008, Pubmed
Craske, Correction: Anxiety disorders. 2017, Pubmed
Cregg, Pharmacogenetics of analgesic drugs. 2013, Pubmed
Cuthbert, Toward the future of psychiatric diagnosis: the seven pillars of RDoC. 2013, Pubmed
Daly, The role of adenosine receptors in the central action of caffeine. 1994, Pubmed
Davidson, Anxiety and affective style: role of prefrontal cortex and amygdala. 2002, Pubmed
Egan, Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish. 2009, Pubmed
Ennaceur, Tests of unconditioned anxiety - pitfalls and disappointments. 2014, Pubmed
Fossat, Comparative behavior. Anxiety-like behavior in crayfish is controlled by serotonin. 2014, Pubmed
Gaetani, Anandamide hydrolysis: a new target for anti-anxiety drugs? 2003, Pubmed
Goswami, Animal models of post-traumatic stress disorder: face validity. 2013, Pubmed
Griebel, 50 years of hurdles and hope in anxiolytic drug discovery. 2013, Pubmed
Griebel, 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. 1995, Pubmed
Harris, The role of the hypothalamus-pituitary-adrenal/interrenal axis in mediating predator-avoidance trade-offs. 2016, Pubmed
Harris, FAAH genotype, CRFR1 genotype, and cortisol interact to predict anxiety in an aging, rural Hispanic population: A Project FRONTIER study. 2019, Pubmed
Hoffman, Anxiety disorders: a comprehensive review of pharmacotherapies. 2008, Pubmed
Hopkins, Amphibians as models for studying environmental change. 2007, Pubmed
Hughes, Evidence for anxiolytic effects of acute caffeine on anxiety-related behavior in male and female rats tested with and without bright light. 2014, Pubmed
Insel, The NIMH Research Domain Criteria (RDoC) Project: precision medicine for psychiatry. 2014, Pubmed
Jain, Anxiolytic activity of adenosine receptor activation in mice. 1995, Pubmed
Jesuthasan, Fear, anxiety, and control in the zebrafish. 2012, Pubmed
Kshama, Modulation of baseline behavior in rats by putative serotonergic agents in three ethoexperimental paradigms. 1990, Pubmed
Kumar, Animal models of anxiety: a comprehensive review. 2013, Pubmed
Kurt, The effects of sertraline and fluoxetine on anxiety in the elevated plus-maze test in mice. 2000, Pubmed
Lampis, Animal models of human anxiety disorders: reappraisal from a developmental psychopathology vantage point. 2011, Pubmed
Lembke, Our Other Prescription Drug Problem. 2018, Pubmed
Lister, Ethologically-based animal models of anxiety disorders. 1990, Pubmed
Liu, Predator-secreted sulfolipids induce defensive responses in C. elegans. 2018, Pubmed
Loonen, Circuits regulating pleasure and happiness: the evolution of reward-seeking and misery-fleeing behavioral mechanisms in vertebrates. 2015, Pubmed
Lowry, Modulation of anxiety circuits by serotonergic systems. 2005, Pubmed
Mansouri, A possible mechanism for the anxiolytic-like effect of gallic acid in the rat elevated plus maze. 2014, Pubmed
Matsuda, Ovine corticotropin-releasing hormone (oCRH) exerts an anxiogenic-like action in the goldfish, Carassius auratus. 2013, Pubmed
Maximino, Parametric analyses of anxiety in zebrafish scototaxis. 2010, Pubmed
Maximino, Scototaxis as anxiety-like behavior in fish. 2010, Pubmed
Maximino, Measuring anxiety in zebrafish: a critical review. 2010, Pubmed
Maximino, Pharmacological analysis of zebrafish (Danio rerio) scototaxis. 2011, Pubmed
Morris, A nematode that can manipulate the behaviour of slugs. 2018, Pubmed
Nestler, Animal models of neuropsychiatric disorders. 2010, Pubmed
Pellow, Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. 1985, Pubmed
Perusini, Neurobehavioral perspectives on the distinction between fear and anxiety. 2015, Pubmed
Prater, Tectal CRFR1 receptors modulate food intake and feeding behavior in the South African clawed frog Xenopus laevis. 2018, Pubmed , Xenbase
Ramos, Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial. 2008, Pubmed
Ramos, Animal models of anxiety: do I need multiple tests? 2008, Pubmed
Ramos, A multiple-test study of anxiety-related behaviours in six inbred rat strains. 1997, Pubmed
Ramos, A genetic and multifactorial analysis of anxiety-related behaviours in Lewis and SHR intercrosses. 1998, Pubmed
Ren, Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. 2018, Pubmed
Ressler, Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. 2007, Pubmed
Richendrfer, On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae. 2012, Pubmed
Rodgers, Animal models of anxiety: an ethological perspective. 1997, Pubmed
Rotzinger, Behavioral effects of neuropeptides in rodent models of depression and anxiety. 2010, Pubmed
Sackerman, Zebrafish Behavior in Novel Environments: Effects of Acute Exposure to Anxiolytic Compounds and Choice of Danio rerio Line. 2010, Pubmed
Shin, From Zebrafish to human: modular medical models. 2002, Pubmed
Silva, Selective serotonin re-uptake inhibitors (SSRIs) in the aquatic environment: an ecopharmacovigilance approach. 2012, Pubmed
Simmons, Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus. 2017, Pubmed
Simon, Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. 1994, Pubmed
Smith, Effects of caffeine on human behavior. 2002, Pubmed
Sokolowski, Wired for behaviors: from development to function of innate limbic system circuitry. 2012, Pubmed
Sommi, Fluoxetine: a serotonin-specific, second-generation antidepressant. 1987, Pubmed
Steimer, Animal models of anxiety disorders in rats and mice: some conceptual issues. 2011, Pubmed
Stewart, Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models. 2011, Pubmed
Stewart, Modeling anxiety using adult zebrafish: a conceptual review. 2012, Pubmed
Stewart, Developing better and more valid animal models of brain disorders. 2015, Pubmed
Stewart, Zebrafish models for translational neuroscience research: from tank to bedside. 2014, Pubmed
Tandon, Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling. 2017, Pubmed , Xenbase
Tierney, Invertebrate serotonin receptors: a molecular perspective on classification and pharmacology. 2018, Pubmed
Tovote, Neuronal circuits for fear and anxiety. 2015, Pubmed
Treit, Animal models of anxiety and anxiolytic drug action. 2010, Pubmed
Trullas, Differences in fear motivated behaviors among inbred mouse strains. 1993, Pubmed
Varty, The gerbil elevated plus-maze I: behavioral characterization and pharmacological validation. 2002, Pubmed
Vendruscolo, Evaluation of the anxiolytic-like effect of NKP608, a NK1-receptor antagonist, in two rat strains that differ in anxiety-related behaviors. 2003, Pubmed
Vetulani, A possible common mechanism of action of antidepressant treatments: reduction in the sensitivity of the noradrenergic cyclic AMP gererating system in the rat limbic forebrain. 1976, Pubmed
Walf, The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. 2007, Pubmed
Williams, Individual variation in endocrine systems: moving beyond the 'tyranny of the Golden Mean'. 2008, Pubmed
Willner, The validity of animal models of depression. 1984, Pubmed
Wong, Analyzing habituation responses to novelty in zebrafish (Danio rerio). 2010, Pubmed
Zohar, Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. 2000, Pubmed
van Mier, The development of serotonergic raphespinal projections in Xenopus laevis. 1986, Pubmed , Xenbase
van der Staay, Evaluation of animal models of neurobehavioral disorders. 2009, Pubmed