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Glycoconj J
2002 Jan 01;191:53-7. doi: 10.1023/a:1022584914778.
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Structure of the main ganglioside from the brain of Xenopus laevis.
Rizzo AM
,
Berra B
,
Rossi F
,
Guerra A
,
Gornati R
,
Bernardini G
,
Taki T
,
Kasama T
,
Mauri L
,
Sonnino S
.
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The main component of the ganglioside(1) mixture from the brain of the adult amphibian Xenopus laevis accounts for 35% of the total, as lipid bound sialic acid. This ganglioside has been purified and characterized by thin layer chromatography, partial and exhaustive enzymatic hydrolysis with sialidase, TLC-overlay procedures with anti-Gg(4)Cer and anti-Neu5Acalpha6GalNAcbeta specific monoclonal antibodies and mass spectrometry. All together the results suggest the following structure: Neu5Acalpha8Neu5Acalpha3Galbeta3(Neu5Acalpha8Neu5Acalpha6)GalNAcbeta4Galbeta4Glcbeta1Cer, or, IV(3)-alpha-Neu5Ac(2),III(6)-alpha-Neu5Ac(2)-Gg(4)Cer.
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