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Medicine (Baltimore)
2018 Nov 01;9746:e13303. doi: 10.1097/MD.0000000000013303.
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Prognostic and clinical value of Targeting protein for Xenopus kinesin-like protein 2 in patients with gastrointestinal tract cancers: A meta-analysis.
Liu W
,
Xu J
,
Zhang C
.
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BACKGROUND: Accumulating studies have indicated that Targeting protein for Xenopus kinesin-like protein 2 (TPX2) was overexpressed in various types of human cancers. However, the prognostic and clinical value of TPX2 in gastrointestinal (GI) tract cancers was not well-understood. This study was aimed to comprehensively explore the prognostic and clinical significance of TPX2 in GI tract cancers.
METHODS: Eligible studies were systematically retrieved in PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang database. The eligible studies were collected to evaluate the association of TPX2 with prognosis and clinicopathological features, with the pooling hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI).
RESULT: The meta-analysis suggested that overexpression of TPX2 protein was significantly correlated with poor overall survival (OS) (HR: 2.20, 95% CI: 1.60-2.80, P <.001) in GI tract cancers, the subgroup meta-analysis also confirmed the prognostic value of TPX2 protein. Furthermore, clinical significances of TPX2 protein in gastric cancer were discussed.
CONCLUSION: Upregulated TPX2 protein was correlated with poor clinical outcomes, suggesting that TPX2 protein can serve as a promising predictive biomarker in patients with GI tract cancers.
Figure 1. The steps for screening eligible articles.
Figure 2. Meta-analysis of the pooled HRs of OS of patients with TPX2 over-expression in GI tract cancers. GI tract = gastrointestinal tract, HR = hazard ratio, OS = overall survival.
Figure 3. Meta-analysis of the pooled HRs of MFS of patients with TPX2 over-expression in GI tract cancers cancers. GI tract = gastrointestinal tract, HR = hazard ratio, MFS = metastasis-free survival, TPX2 = Targeting protein for Xenopus kinesin-like protein 2.
Figure 4. Publication bias test for OS. OS = overall survival.
Figure 5. Sensitivity analysis for OS. OS = overall survival.
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