Bioessays 2003 Apr 01;254:313-6. doi: 10.1002/bies.10264.

Block to DNA replication in meiotic maturation: a unified view for a robust arrest of cell cycle in oocytes and somatic cells.

???displayArticle.abstract???
Under certain conditions, the cell cycle can be arrested for a long period of time. Vertebrate oocytes are arrested at G(2) phase, while somatic cells arrest at G(0) phase. In both cells, nuclei have lost the ability to initiate DNA synthesis. In a pair of recently published papers,[1,2] Méchali and colleagues and Coué and colleagues have clarified how frog oocytes prevent untimely DNA synthesis during the long G(2) arrest. Intriguingly, they found only Cdc6 is responsible for the inability of immature oocytes to replicate DNA. Cdc6 is a key component for replication licensing, and for G(0) cells to re-enter the proliferative stage. Strikingly similar strategies for preventing the untimely replication in both cells suggest that the suppression of replication licensing is a universal mechanism for securing the prolonged arrest of the cell cycle.

???displayArticle.pubmedLink??? 12655638
???displayArticle.link??? Bioessays


Species referenced: Xenopus laevis
Genes referenced: cdc6