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XB-ART-5516
Bioorg Med Chem Lett 2003 Apr 17;138:1437-9. doi: 10.1016/s0960-894x(03)00156-2.
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Novel openers of Ca2+-dependent large-conductance potassium channels: symmetrical pharmacophore and electrophysiological evaluation of bisphenols.

Li Y , Johnson G , Romine JL , Meanwell NA , Martin SW , Dworetzky SI , Boissard CG , Gribkoff VK , Starrett JE .


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Electrophysiological evaluation of symmetrical analogues of the known maxi-K opener NS-004 (1) led to the discovery of bisphenols 2a, 3a and 4a as openers of cloned maxi-K channels expressed in oocytes.

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