XB-ART-54376
Biochemistry
2017 Nov 14;5645:6051-6060. doi: 10.1021/acs.biochem.7b00485.
Show Gene links
Show Anatomy links
Structure and Biological Activity of a Turripeptide from Unedogemmula bisaya Venom.
???displayArticle.abstract???
The turripeptide ubi3a was isolated from the venom of the marine gastropod Unedogemmula bisaya, family Turridae, by bioassay-guided purification; both native and synthetic ubi3a elicited prolonged tremors when injected intracranially into mice. The sequence of the peptide, DCCOCOAGAVRCRFACC-NH 2 (O = 4-hydroxyproline) follows the framework III pattern for cysteines (CC-C-C-CC) in the M-superfamily of conopeptides. The three-dimensional structure determined by NMR spectroscopy indicated a disulfide connectivity that is not found in conopeptides with the cysteine framework III: C 1 -C 4, C 2 -C 6 , C 3 -C 5 . The peptide inhibited the activity of the α9α10 nicotinic acetylcholine receptor with relatively low affinity (IC 50 , 10.2 μM). Initial Constellation Pharmacology data revealed an excitatory activity of ubi3a on a specific subset of mouse dorsal root ganglion neurons.
???displayArticle.pubmedLink??? 29090914
???displayArticle.link??? Biochemistry
???displayArticle.grants???