XB-ART-54026
Bioorg Med Chem Lett
2017 Sep 15;2718:4512-4513. doi: 10.1016/j.bmcl.2017.07.050.
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Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA).
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Investigations into the pharmacology of different types of cys-loop GABA receptor have relied for years on the chemical modification of GABA-like compounds. The GABA metabolite GABOB is an attractive molecule to modify due to its convenient chemical structure. In the process of developing new GABA-mimic compounds from GABOB as a starting compound three small molecule GABA derivatives were synthesized using a variety of chemical transformations. Amongst these, a new and reliable method to synthesize TACA (trans-4-aminocrotonic acid) is reported.
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Species referenced: Xenopus laevis
Genes referenced: gabarap