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XB-ART-53796
J Leukoc Biol 2017 Sep 01;1023:845-855. doi: 10.1189/jlb.1A0317-082RR.
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Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse.

Hassnain Waqas SF , Noble A , Hoang AC , Ampem G , Popp M , Strauß S , Guille M , Röszer T .


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ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident Mϕs are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.

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Species referenced: Xenopus laevis
Genes referenced: atm itgam npff npffr1.1 ptprc rnf128 tal1
Lines/Strains:

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References [+] :
Ablamunits, Reduced adiposity in ob/ob mice following total body irradiation and bone marrow transplantation. 2007, Pubmed