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Rouxs Arch Dev Biol
1991 Jun 01;2001:4-7. doi: 10.1007/BF02457635.
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Follistatin inhibits the mesoderm-inducing activity of activin A and the vegetalizing factor from chicken embryo.
Asashima M
,
Nakano H
,
Uchiyama H
,
Sugino H
,
Nakamura T
,
Eto Y
,
Ejima D
,
Davids M
,
Plessow S
,
Cichocka I
,
Kinoshita K
.
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The induction of mesoderm is an important process in early amphibian development. In recent studies, activin has become an effective candidate for a natural mesoderm-inducing factor. In the present study, we show that follistatin, an activin-binding protein purified from porcine ovary, inhibits the mesoderm-inducing activity of recombinant human activin A (rh activin A), which is identical to the erythroid differentiation factor (EDF). The quantity of follistatin required for effective suppression of activin was more than three-fold that of activin (w:w). Follistatin also inhibited the mesoderm-inducing activity of the vegetalizing factor purified from chick embryos, suggesting that the vegetalizing factor is closely related to activin.
Asashima,
Inducing effects of the presumptive endoderm of successive stages inTriturus alpestris.
1975, Pubmed
Asashima,
Inducing effects of the presumptive endoderm of successive stages inTriturus alpestris.
1975,
Pubmed
Asashima,
The vegetalizing factor belongs to a family of mesoderm-inducing proteins related to erythroid differentiation factor.
1990,
Pubmed
,
Xenbase
Asashima,
Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor).
1990,
Pubmed
,
Xenbase
Carroll,
Inhibin, activin, and follistatin: regulation of follicle-stimulating hormone messenger ribonucleic acid levels.
1989,
Pubmed
Esch,
Structural characterization of follistatin: a novel follicle-stimulating hormone release-inhibiting polypeptide from the gonad.
1987,
Pubmed
Eto,
Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1.
1987,
Pubmed
Geithe,
A vegetalizing inducing factor. Isolation and chemical properties.
1981,
Pubmed
Green,
The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF.
1990,
Pubmed
,
Xenbase
Grunz,
A mesoderm-inducing factor from a Xenopus laevis cell line : Chemical properties and relation to the vegetalizing factor from chicken embryos.
1989,
Pubmed
,
Xenbase
Grunz,
Induction of mesodermal tissues by acidic and basic heparin binding growth factors.
1988,
Pubmed
,
Xenbase
Gurdon,
Activation of muscle-specific actin genes in Xenopus development by an induction between animal and vegetal cells of a blastula.
1985,
Pubmed
,
Xenbase
Kimelman,
Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.
1987,
Pubmed
,
Xenbase
Knöchel,
Mesoderm induction by transforming growth factor beta: medium conditioned by TGF-beta-treated ectoderm enhances the inducing activity.
1989,
Pubmed
,
Xenbase
Knöchel,
Mesoderm-inducing factors. Their possible relationship to heparin-binding growth factors and transforming growth factor-beta.
1987,
Pubmed
Mason,
Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta.
,
Pubmed
Murata,
Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.
1988,
Pubmed
Nakamura,
Activin-binding protein from rat ovary is follistatin.
1990,
Pubmed
Nieuwkoop,
The formation of the mesoderm in urodelean amphibians : IV. Qualitative evidence for the purely "ectodermal" origin of the entire mesoderm and of the pharyngeal endoderm.
1972,
Pubmed
Paterno,
Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF.
1989,
Pubmed
,
Xenbase
Plessow,
Isolation of a vegetalizing inducing factor after extraction with acid ethanol. Concentration-dependent inducing capacity of the factor.
1990,
Pubmed
,
Xenbase
Robertson,
The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin.
1987,
Pubmed
Rosa,
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.
1988,
Pubmed
,
Xenbase
Slack,
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.
,
Pubmed
,
Xenbase
Smith,
Mesoderm induction and mesoderm-inducing factors in early amphibian development.
1989,
Pubmed
Smith,
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
1990,
Pubmed
,
Xenbase
Thomsen,
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.
1990,
Pubmed
,
Xenbase
Ueno,
Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.
1987,
Pubmed
Vale,
Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid.
,
Pubmed
van den Eijnden-Van Raaij,
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction.
1990,
Pubmed
,
Xenbase
