XB-ART-53088
Results Probl Cell Differ
2017 Jan 01;59:175-200. doi: 10.1007/978-3-319-44820-6_6.
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Translational Control of Germ Cell Decisions.
Pushpa K
,
Kumar GA
,
Subramaniam K
.
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Germline poses unique challenges to gene expression control at the transcriptional level. While the embryonic germline maintains a global hold on new mRNA transcription, the female adult germline produces transcripts that are not translated into proteins until embryogenesis of subsequent generation. As a consequence, translational control plays a central role in governing various germ cell decisions including the formation of primordial germ cells, self-renewal/differentiation decisions in the adult germline, onset of gametogenesis and oocyte maturation. Mechanistically, several common themes such as asymmetric localization of mRNAs, conserved RNA-binding proteins that control translation by 3' UTR binding, translational activation by the cytoplasmic elongation of the polyA tail and the assembly of mRNA-protein complexes called mRNPs have emerged from the studies on Caenorhabditis elegans, Xenopus and Drosophila. How mRNPs assemble, what influences their dynamics, and how a particular 3' UTR-binding protein turns on the translation of certain mRNAs while turning off other mRNAs at the same time and space are key challenges for future work.
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???displayArticle.grants??? [+]
IA/E/13/1/501266 Wellcome Trust-DBT India Alliance, IA/E/13/1/501266 DBT-Wellcome Trust India Alliance
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