J Med Assoc Thai 2015 Nov 01;98 Suppl 10:S118-23.

Xanthones Isolated from the Pericarp of Mangosteen Inhibit Neurotransmitter Receptors Expressed in Xenopus Oocytes.

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This study aimed to evaluate inhibitory effects of 7 xanthones and 3 extracts obtained from the pericarp of mangosteen on serotonin (5-HT), N-methyl-D-aspartate (NMDA) and glycine receptors expressed in Xenopus oocytes. Xenopus oocytes were injected with RNA of either 5-HT NMDA or glycine receptor and inhibitory effects of the xanthones and extracts were investigated using the two-electrode voltage clamp technique. Xanthones from the pericarp of mangosteen affected 5-HT NMDA and glycine receptor functions with different degree of inhibition. Alpha-mangostin, garcinone-D and 9-hydroxycalaba xanthone inhibited 5-H T-induced currents by more than 80%. Gamma-mangostin and garcinone-E did by more than 50%, but not more than 80%. Garcinone-C and garcinone- D inhibited glutamate-induced currents by more than 80%. The alcohol extract did by more than 50%, but not more than 80%. Alpha-mangostin, garcinone-C, garcinone-D, non-tannin extract and the alcohol extract inhibited glycine-induced currents between 50-70%, neither compounds inhibited the currents up to 80%. These results suggest that each xanthone derivatives has different selectivity to different types of neurotransmitter receptors.

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