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XB-ART-52394
Food Chem 2017 Jan 01;214:354-359. doi: 10.1016/j.foodchem.2016.07.048.
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Direct activation of GABAA receptors by substances in the organic acid fraction of Japanese sake.

Izu H , Shigemori K , Eguchi M , Kawane S , Fujii S , Kitamura Y , Aoshima H , Yamada Y .


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We investigated the effect of substances present in Japanese sake on the response of ionotropic γ-aminobutyric acid (GABA)A receptors expressed in Xenopus oocytes. Sake was fractionated by ion-exchange chromatography. The fraction containing organic acids (OA fraction) showed agonist activities on the GABAA receptor. OA fractions from sake were analyzed by capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). Of the 64 compounds identified, 13 compounds showed GABAA receptor agonist activities. Especially, l-lactic acid showed high agonist activity and its EC50 value was 37μM. Intraperitoneal injections of l-lactic acid, gluconic acid, and pyruvic acid (10, 10, and 5mg/kg BW, respectively), which showed agonistic activity on the GABAA receptor, led to significant anxiolytic effects during an elevated plus-maze test in mice.

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Species referenced: Xenopus laevis
Genes referenced: gabarap