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A bundle of microtubules known as the spindle midzone is rapidly assembled after anaphase onset, recruiting multiple signaling proteins that regulate cytokinesis. A new study reveals that positive feedback driven by clustering of a kinesin-6 motor underlies the explosive assembly of the spindle midzone.
Ban,
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.
2004, Pubmed
Ban,
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.
2004,
Pubmed
D'Avino,
How to scaffold the contractile ring for a safe cytokinesis - lessons from Anillin-related proteins.
2009,
Pubmed
Foe,
Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation.
2008,
Pubmed
Fu,
Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.
2009,
Pubmed
Holt,
Positive feedback sharpens the anaphase switch.
2008,
Pubmed
Hutterer,
Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody.
2009,
Pubmed
Lindqvist,
The decision to enter mitosis: feedback and redundancy in the mitotic entry network.
2009,
Pubmed
Mishima,
Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.
2002,
Pubmed
Mishima,
Cell cycle regulation of central spindle assembly.
2004,
Pubmed
Mollinari,
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone.
2002,
Pubmed
Odell,
An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning.
2008,
Pubmed
Somers,
A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis.
2003,
Pubmed
Wolfe,
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
2009,
Pubmed
Zhu,
Spatiotemporal control of spindle midzone formation by PRC1 in human cells.
2006,
Pubmed
