Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Biophys J
2014 Nov 18;10710:2345-51. doi: 10.1016/j.bpj.2014.10.005.
Show Gene links
Show Anatomy links
Identifying transport behavior of single-molecule trajectories.
Regner BM
,
Tartakovsky DM
,
Sejnowski TJ
.
???displayArticle.abstract???
Models of biological diffusion-reaction systems require accurate classification of the underlying diffusive dynamics (e.g., Fickian, subdiffusive, or superdiffusive). We use a renormalization group operator to identify the anomalous (non-Fickian) diffusion behavior from a short trajectory of a single molecule. The method provides quantitative information about the underlying stochastic process, including its anomalous scaling exponent. The classification algorithm is first validated on simulated trajectories of known scaling. Then it is applied to experimental trajectories of microspheres diffusing in cytoplasm, revealing heterogeneous diffusive dynamics. The simplicity and robustness of this classification algorithm makes it an effective tool for analysis of rare stochastic events that occur in complex biological systems.
Arcizet,
Temporal analysis of active and passive transport in living cells.
2008, Pubmed
Arcizet,
Temporal analysis of active and passive transport in living cells.
2008,
Pubmed
Bouzigues,
Transient directed motions of GABA(A) receptors in growth cones detected by a speed correlation index.
2007,
Pubmed
Deng,
Ergodic properties of fractional Brownian-Langevin motion.
2009,
Pubmed
Gal,
Experimental evidence of strong anomalous diffusion in living cells.
2010,
Pubmed
He,
Random time-scale invariant diffusion and transport coefficients.
2008,
Pubmed
Huet,
Analysis of transient behavior in complex trajectories: application to secretory vesicle dynamics.
2006,
Pubmed
Höfling,
Anomalous transport in the crowded world of biological cells.
2013,
Pubmed
Javer,
Short-time movement of E. coli chromosomal loci depends on coordinate and subcellular localization.
2013,
Pubmed
Kepten,
Improved estimation of anomalous diffusion exponents in single-particle tracking experiments.
2013,
Pubmed
Magdziarz,
Fractional brownian motion versus the continuous-time random walk: a simple test for subdiffusive dynamics.
2009,
Pubmed
Michalet,
Mean square displacement analysis of single-particle trajectories with localization error: Brownian motion in an isotropic medium.
2010,
Pubmed
Min,
Observation of a power-law memory kernel for fluctuations within a single protein molecule.
2005,
Pubmed
O'Malley,
Two-scale renormalization-group classification of diffusive processes.
2012,
Pubmed
Park,
Generalized similarity, renormalization groups, and nonlinear clocks for multiscaling.
2014,
Pubmed
Qian,
Single particle tracking. Analysis of diffusion and flow in two-dimensional systems.
1991,
Pubmed
Regner,
Anomalous diffusion of single particles in cytoplasm.
2013,
Pubmed
,
Xenbase
Tabei,
Intracellular transport of insulin granules is a subordinated random walk.
2013,
Pubmed
Weigel,
Ergodic and nonergodic processes coexist in the plasma membrane as observed by single-molecule tracking.
2011,
Pubmed
