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XB-ART-50901
PLoS One 2015 Jun 05;106:e0128578. doi: 10.1371/journal.pone.0128578.
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The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

Camargos TS , Bosmans F , Rego SC , Mourão CB , Schwartz EF .


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We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function.

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Species referenced: Xenopus
Genes referenced: nav1 scn3a


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References [+] :
Alami, Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels. 2003, Pubmed, Xenbase