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Cell Res
2013 Jun 01;236:737-8. doi: 10.1038/cr.2013.51.
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Unwinding the Wnt action of casein kinase 1.
Yim DG
,
Virshup DM
.
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The casein kinase 1 (CK1) family, a major intracellular serine/threonine kinase, is implicated in multiple pathways; however, understanding its regulation has proven challenging. A recent study published in Science identifying allosteric activation of CK1 by the DEAD-box RNA helicase DDX3 expands our understanding of the control of this abundant kinase family.
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Cheong,
Casein kinase 1: Complexity in the family.
2011, Pubmed
Cheong,
Casein kinase 1: Complexity in the family.
2011,
Pubmed
Cruciat,
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.
2013,
Pubmed
,
Xenbase
Dahlberg,
Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity.
2009,
Pubmed
,
Xenbase
Davidson,
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.
2005,
Pubmed
,
Xenbase
Flotow,
Phosphate groups as substrate determinants for casein kinase I action.
1990,
Pubmed
Gao,
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
2002,
Pubmed
,
Xenbase
Lindsley,
Whence cometh the allosterome?
2006,
Pubmed
Okamura,
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
2004,
Pubmed
Schröder,
Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation.
2010,
Pubmed
Swiatek,
Regulation of casein kinase I epsilon activity by Wnt signaling.
2004,
Pubmed
,
Xenbase
Thorne,
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
2010,
Pubmed
,
Xenbase
Zeng,
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.
2005,
Pubmed
,
Xenbase
