Comb Chem High Throughput Screen 2003 Aug 01;65:481-8. doi: 10.2174/138620703106298653.

Parallel synthesis of a biased library of thiazolidinones as novel sodium channel antagonists.

???displayArticle.abstract???
A biased chemical library containing 91 differentially substituted thiazolidinones was prepared in an effort to improve the pharmacology of a known anticonvulsant agent V102862. The collection was prepared in a single step multi-component condensation reaction that produced good yields and very high crude purity (75%-85%). Seven compounds, identified within the library were shown to be more potent than V102862, our parent reference compound, in an electrophysiological assay measuring sodium channel antagonism. The most potent compound, 3-(2-piperidinylethyl)-2-(3-(3-trifluoromethylphenoxy)phenyl)thiazolidinone, has a Ki of 90 nM.

???displayArticle.pubmedLink??? 12871054
???displayArticle.link??? Comb Chem High Throughput Screen