Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
A molecule bearing an immunoglobulin-like V region of the CTX subfamily in amphioxus.
Sato A
,
Mayer WE
,
Klein J
.
???displayArticle.abstract???
An expressed sequence tag with significant similarity to a vertebrate T-cell receptor (Tcr) sequence was found in a cDNA library prepared from the posterior part of the adult amphioxus, Branchiostoma lanceolatum ( Brla). Characterization of the corresponding cDNA clone revealed the presence of an open reading frame encoding a 351 amino acid residue-long polypeptide. The putative protein, tentatively designated Brla-VDB for "V-domain bearing", appears to consist of two domains. The N-terminal domain begins with a putative leader peptide followed by a sequence resembling the V domain of the CTX protein originally found to be expressed in the cortical thymocytes of the clawed frog Xenopus. The C-terminal domain of the VDB protein does not show significant sequence similarity to any entry in the databases and contains five hydrophobic segments separated by short intervening hydrophilic stretches. It may therefore belong to a protein that crosses the plasma membrane five times. These findings support the notion that V domains resembling those found in Tcrs evolved in nonvertebrates before the emergence of the adaptive immune system and may have participated in functions not involved directly in immunity.
Babic,
SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47.
2000, Pubmed
Babic,
SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47.
2000,
Pubmed
Bergelson,
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.
1997,
Pubmed
Boucheix,
Tetraspanins.
2001,
Pubmed
Cannon,
Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate.
2002,
Pubmed
Chrétien,
CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates.
1998,
Pubmed
,
Xenbase
Chrétien,
CTX, a novel molecule specifically expressed on the surface of cortical thymocytes in Xenopus.
1996,
Pubmed
,
Xenbase
Chung,
Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.
1997,
Pubmed
Frazier,
The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi.
1999,
Pubmed
Gao,
Thrombospondin modulates alpha v beta 3 function through integrin-associated protein.
1996,
Pubmed
Green,
Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins.
1999,
Pubmed
Halaby,
The immunoglobulin superfamily: an insight on its tissular, species, and functional diversity.
1998,
Pubmed
Han,
CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation.
2000,
Pubmed
Harpaz,
Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains.
1994,
Pubmed
Heath,
The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily.
1997,
Pubmed
Jayasinghe,
MPtopo: A database of membrane protein topology.
2001,
Pubmed
Katevuo,
ChT1, an Ig superfamily molecule required for T cell differentiation.
1999,
Pubmed
,
Xenbase
Krogh,
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
2001,
Pubmed
Lindberg,
Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding.
1996,
Pubmed
Lindberg,
Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding.
1993,
Pubmed
Maecker,
The tetraspanin superfamily: molecular facilitators.
1997,
Pubmed
Mayer,
Isolation and characterization of lymphocyte-like cells from a lamprey.
2002,
Pubmed
McGuffin,
The PSIPRED protein structure prediction server.
2000,
Pubmed
Mendoza,
Physiological aspects of the immunoglobulin superfamily in invertebrates.
1999,
Pubmed
Rebres,
Membrane raft association of CD47 is necessary for actin polymerization and protein kinase C theta translocation in its synergistic activation of T cells.
2001,
Pubmed
Reinhold,
Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway.
1997,
Pubmed
Sato,
Persistence of Mhc heterozygosity in homozygous clonal killifish, Rivulus marmoratus: implications for the origin of hermaphroditism.
2002,
Pubmed
Todres,
The tetraspanin superfamily in insects.
2000,
Pubmed
Tomko,
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.
1997,
Pubmed
Wang,
The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells.
1998,
Pubmed