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XB-ART-48733
Bioorg Med Chem Lett 2014 Apr 15;248:1963-7. doi: 10.1016/j.bmcl.2014.02.067.
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Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.

Janganati V , Penthala NR , Cragle CE , MacNicol AM , Crooks PA .


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Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression.

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References [+] :
Bagowski, The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes. 2001, Pubmed, Xenbase