XB-ART-47985
J Am Soc Nephrol
2013 Sep 01;249:1347-56. doi: 10.1681/ASN.2012121199.
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Human kidney cell reprogramming: applications for disease modeling and personalized medicine.
O'Neill AC
,
Ricardo SD
.
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The ability to reprogram fully differentiated cells into a pluripotent embryonic state, termed induced pluripotent stem cells (iPSCs), has been met with great excitement. iPSC technology has advanced the fundamental study of disease modeling with the potential for cell-replacement therapy, especially in the neuronal and cardiac fields. However, renal medicine as of yet has not benefited from similar advancements. This review summarizes the unique characteristics of iPSCs and their potential applications for modeling kidney disease. Pioneering such endeavors could yield constructs that recapitulate disease phenotypes, open avenues for more targeted drug development, and potentially serve as replenishable sources for replacement of kidney cells in the setting of human disease.
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References [+] :
Aasen,
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes.
2008, Pubmed
Aasen, Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. 2008, Pubmed
Agarwal, Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. 2010, Pubmed
Ahmed, Reprogramming of skeletal myoblasts for induction of pluripotency for tumor-free cardiomyogenesis in the infarcted heart. 2011, Pubmed
Angelotti, Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. 2012, Pubmed
Appel, Recruitment of podocytes from glomerular parietal epithelial cells. 2009, Pubmed
Bankir, Urinary concentrating ability: insights from comparative anatomy. 1985, Pubmed
Barisoni, Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. 2000, Pubmed
Beqqali, Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. 2006, Pubmed
Bi, Stromal cells protect against acute tubular injury via an endocrine effect. 2007, Pubmed
Blau, How fixed is the differentiated state? Lessons from heterokaryons. 1989, Pubmed
Bock, Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. 2011, Pubmed
Bonventre, Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. 2003, Pubmed
Brennan, The specification and growth factor inducibility of the pronephric glomus in Xenopus laevis. 1999, Pubmed , Xenbase
Brennand, Modelling schizophrenia using human induced pluripotent stem cells. 2011, Pubmed
Bruce, In vitro differentiation of murine embryonic stem cells toward a renal lineage. 2007, Pubmed
Cai, Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. 2010, Pubmed
Chin, Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. 2009, Pubmed
Chun, Induced pluripotent stem cells and personalized medicine: current progress and future perspectives. 2011, Pubmed
Cochrane, Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. 2005, Pubmed
Cotte, Identification of residues responsible for the selective binding of peptide antagonists and agonists in the V2 vasopressin receptor. 1998, Pubmed
D'Agati, Podocyte injury in focal segmental glomerulosclerosis: Lessons from animal models (a play in five acts). 2008, Pubmed
DiBerardino, Gene reactivation in erythrocytes: nuclear transplantation in oocytes and eggs of Rana. 1983, Pubmed
Diep, Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. 2011, Pubmed
Dimos, Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. 2008, Pubmed
Ebert, Induced pluripotent stem cells from a spinal muscular atrophy patient. 2009, Pubmed
González, Methods for making induced pluripotent stem cells: reprogramming à la carte. 2011, Pubmed
Griffin, Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. 2004, Pubmed
Gurdon, The first half-century of nuclear transplantation. 2003, Pubmed
Gurdon, The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. 1975, Pubmed , Xenbase
Haase, Generation of induced pluripotent stem cells from human cord blood. 2009, Pubmed
Han, Direct reprogramming of fibroblasts into neural stem cells by defined factors. 2012, Pubmed
Hartman, Cessation of renal morphogenesis in mice. 2007, Pubmed
Hendry, Reprogramming the kidney: a novel approach for regeneration. 2012, Pubmed
Hendry, Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. 2013, Pubmed
Hochedlinger, Monoclonal mice generated by nuclear transfer from mature B and T donor cells. 2002, Pubmed
Hu, Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation. 2010, Pubmed
Huangfu, Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. 2008, Pubmed
Humphreys, Repair of injured proximal tubule does not involve specialized progenitors. 2011, Pubmed
Humphreys, Intrinsic epithelial cells repair the kidney after injury. 2008, Pubmed
Ichida, A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. 2009, Pubmed
Itzhaki, Modelling the long QT syndrome with induced pluripotent stem cells. 2011, Pubmed
Jans, A simple method for obtaining functionally and morphologically intact primary cultures of the medullary thick ascending limb of Henle's loop (MTAL) from rabbit kidneys. 2000, Pubmed
Kim, Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. 2005, Pubmed
Kim, Epigenetic memory in induced pluripotent stem cells. 2010, Pubmed
Kobayashi, Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. 2005, Pubmed
Kriz, Progressive renal failure--inability of podocytes to replicate and the consequences for development of glomerulosclerosis. 1996, Pubmed
Kriz, The structural organization of the mouse kidney. 1974, Pubmed
Laurent, Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. 2011, Pubmed
Lee, Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. 2009, Pubmed
Lin, Subfractionation of differentiating human embryonic stem cell populations allows the isolation of a mesodermal population enriched for intermediate mesoderm and putative renal progenitors. 2010, Pubmed
Liu, Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. 2011, Pubmed
Mae, Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. 2010, Pubmed
Marchetto, A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. 2010, Pubmed
Matsusaka, Podocyte injury damages other podocytes. 2011, Pubmed
Moretti, Patient-specific induced pluripotent stem-cell models for long-QT syndrome. 2010, Pubmed
Mundel, Induction of differentiation in cultured rat and human podocytes. 1997, Pubmed
Nazor, Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. 2012, Pubmed
Nguyen, LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. 2011, Pubmed
Ohi, Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. 2011, Pubmed
Osafune, In vitro induction of the pronephric duct in Xenopus explants. 2002, Pubmed , Xenbase
Park, Reprogramming of human somatic cells to pluripotency with defined factors. 2008, Pubmed
Pavenstädt, Cell biology of the glomerular podocyte. 2003, Pubmed
Polo, Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. 2010, Pubmed
Racusen, Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines. 1997, Pubmed
Reinders, Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation. 2010, Pubmed
Reiser, Induction of B7-1 in podocytes is associated with nephrotic syndrome. 2004, Pubmed
Reynolds, Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. 1992, Pubmed
Ronconi, Regeneration of glomerular podocytes by human renal progenitors. 2009, Pubmed
Rumballe, Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. 2011, Pubmed
Sagrinati, Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. 2006, Pubmed
Saleem, A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. 2002, Pubmed
Schuldiner, Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. 2000, Pubmed
Semedo, Early modulation of inflammation by mesenchymal stem cell after acute kidney injury. 2009, Pubmed
Shankland, Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation. 2000, Pubmed
Shankland, Podocytes in culture: past, present, and future. 2007, Pubmed
Shi, Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. 2008, Pubmed
Song, Generation of induced pluripotent stem cells from human kidney mesangial cells. 2011, Pubmed
Song, The directed differentiation of human iPS cells into kidney podocytes. 2012, Pubmed
Steenhard, Integration of embryonic stem cells in metanephric kidney organ culture. 2005, Pubmed
Sun, Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. 2009, Pubmed
Susztak, Animal models of renal disease. 2008, Pubmed
Takahashi, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 2006, Pubmed
Takahashi, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. 2007, Pubmed
Thatava, Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation. 2011, Pubmed
Tiscornia, Diseases in a dish: modeling human genetic disorders using induced pluripotent cells. 2011, Pubmed
Tögel, Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. 2005, Pubmed
Unbekandt, Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues. 2010, Pubmed
Vigneau, Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo. 2007, Pubmed
Wagner, A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. 2003, Pubmed
Wharram, Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. 2005, Pubmed
Wiggins, The spectrum of podocytopathies: a unifying view of glomerular diseases. 2007, Pubmed
Wilmut, Viable offspring derived from fetal and adult mammalian cells. 1997, Pubmed
Wise, Mesenchymal stem cells in kidney inflammation and repair. 2012, Pubmed
Woodcock, The prospects for "personalized medicine" in drug development and drug therapy. 2007, Pubmed
Xinaris, In vivo maturation of functional renal organoids formed from embryonic cell suspensions. 2012, Pubmed
Yazawa, Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. 2011, Pubmed
Yuan, VEGF-modified human embryonic mesenchymal stem cell implantation enhances protection against cisplatin-induced acute kidney injury. 2011, Pubmed
Zhang, A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. 2011, Pubmed
Zhou, Generation of human induced pluripotent stem cells from urine samples. 2012, Pubmed
Zhou, Generation of induced pluripotent stem cells from urine. 2011, Pubmed