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Klos Dehring DA
,
Vladar EK
,
Werner ME
,
Mitchell JW
,
Hwang P
,
Mitchell BJ
.
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The ability of cells to faithfully duplicate their two centrioles once per cell cycle is critical for proper mitotic progression and chromosome segregation. Multiciliated cells represent an interesting variation of centriole duplication in that these cells generate greater than 100 centrioles, which form the basal bodies of their motile cilia. This centriole amplification is proposed to require a structure termed the deuterosome, thought to be capable of promoting de novo centriole biogenesis. Here, we begin to molecularly characterize the deuterosome and identify it as a site for the localization of Cep152, Plk4, and SAS6. Additionally we identify CCDC78 as a centriole-associated and deuterosome protein that is essential for centriole amplification. Overexpression of Cep152, but not Plk4, SAS6, or CCDC78, drives overamplification of centrioles. However, in CCDC78 morphants, Cep152 fails to localize to the deuterosome and centriole biogenesis is impaired, indicating that CCDC78-mediated recruitment of Cep152 is required for deuterosome-mediated centriole biogenesis.
Afzelius,
A human syndrome caused by immotile cilia.
1976, Pubmed
Afzelius,
A human syndrome caused by immotile cilia.
1976,
Pubmed
Anderson,
The formation of basal bodies (centrioles) in the Rhesus monkey oviduct.
1971,
Pubmed
Bettencourt-Dias,
SAK/PLK4 is required for centriole duplication and flagella development.
2005,
Pubmed
Blachon,
Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication.
2008,
Pubmed
Brito,
Deconstructing the centriole: structure and number control.
2012,
Pubmed
Brownlee,
Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification.
2013,
Pubmed
Bush,
Primary ciliary dyskinesia: diagnosis and standards of care.
1998,
Pubmed
Cizmecioglu,
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.
2010,
Pubmed
Delattre,
Sequential protein recruitment in C. elegans centriole formation.
2006,
Pubmed
Dirksen,
Ciliary activity in the mouse oviduct as studied by transmission and scanning electron microscopy.
1972,
Pubmed
Dirksen,
Centriole morphogenesis in developing ciliated epithelium of the mouse oviduct.
1971,
Pubmed
Dzhindzhev,
Asterless is a scaffold for the onset of centriole assembly.
2010,
Pubmed
Gavet,
Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells.
2003,
Pubmed
Gopalakrishnan,
Self-assembling SAS-6 multimer is a core centriole building block.
2010,
Pubmed
Habedanck,
The Polo kinase Plk4 functions in centriole duplication.
2005,
Pubmed
Hatch,
Cep152 interacts with Plk4 and is required for centriole duplication.
2010,
Pubmed
,
Xenbase
Kalnins,
Centriole replication during ciliogenesis in the chick tracheal epithelium.
1969,
Pubmed
Kitagawa,
Structural basis of the 9-fold symmetry of centrioles.
2011,
Pubmed
Kleylein-Sohn,
Plk4-induced centriole biogenesis in human cells.
2007,
Pubmed
Kubo,
Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis.
1999,
Pubmed
,
Xenbase
Majczenko,
Dominant mutation of CCDC78 in a unique congenital myopathy with prominent internal nuclei and atypical cores.
2012,
Pubmed
Marshall,
Cilia orientation and the fluid mechanics of development.
2008,
Pubmed
Muresan,
Gamma-tubulin in differentiated cell types: localization in the vicinity of basal bodies in retinal photoreceptors and ciliated epithelia.
1993,
Pubmed
Nigg,
The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries.
2011,
Pubmed
Park,
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells.
2008,
Pubmed
,
Xenbase
Pearson,
Plk4/SAK/ZYG-1 in the regulation of centriole duplication.
2010,
Pubmed
Peel,
Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.
2007,
Pubmed
Sawamoto,
New neurons follow the flow of cerebrospinal fluid in the adult brain.
2006,
Pubmed
Sillibourne,
Autophosphorylation of polo-like kinase 4 and its role in centriole duplication.
2010,
Pubmed
Sonnen,
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
2013,
Pubmed
Sorokin,
Reconstructions of centriole formation and ciliogenesis in mammalian lungs.
1968,
Pubmed
Staprans,
Microtubule protein during ciliogenesis in the mouse oviduct.
1974,
Pubmed
Steinman,
An electron microscopic study of ciliogenesis in developing epidermis and trachea in the embryo of Xenopus laevis.
1968,
Pubmed
,
Xenbase
Stubbs,
Radial intercalation of ciliated cells during Xenopus skin development.
2006,
Pubmed
,
Xenbase
Stubbs,
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos.
2008,
Pubmed
,
Xenbase
Stubbs,
Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.
2012,
Pubmed
,
Xenbase
Tanos,
Centriole distal appendages promote membrane docking, leading to cilia initiation.
2013,
Pubmed
van Breugel,
Structures of SAS-6 suggest its organization in centrioles.
2011,
Pubmed
Vladar,
Molecular characterization of centriole assembly in ciliated epithelial cells.
2007,
Pubmed
Werner,
Using Xenopus skin to study cilia development and function.
2013,
Pubmed
,
Xenbase
Werner,
Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells.
2011,
Pubmed
,
Xenbase
Werner,
Understanding ciliated epithelia: the power of Xenopus.
2012,
Pubmed
,
Xenbase
You,
Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population.
2002,
Pubmed
