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Dev Cell
2012 Dec 11;236:1121-2. doi: 10.1016/j.devcel.2012.11.011.
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Making limbs from fins.
Schneider I
,
Shubin NH
.
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Our limbs evolved from fish fins as vertebrates colonized aquatic shallows and land. If we understood the genetics underlying this transition, could we build a limb on a fish? In this issue of Developmental Cell, Freitas et al. (2012) show that boosting Hoxd13 expression can bring zebrafish one step closer to terra firma.
Figure 1. hoxd13a Overexpression Promotes Increased Cell Proliferation and hoxa13b Expression in the FinfoldThe fins of wild-type zebrafish (upper left) at 90 hr postfertilization (hpf) are composed of an endoskeletal disc (Ed) and a finfold (Ff). Cell proliferation as a measure of the number of nuclei (blue) stained with BrdU (red) is generally restricted to the tip of the endoskeletal territory in wild-type fins at 150 hpf (center left). At 120 hpf, the expression domain of hoxa13b is limited to the endoskeletal disc (bottom left). Glucocorticoid-mediated hoxd13a overexpression (hoxd13a-GR) causes truncation of the finfold (upper right), increased cell proliferation (center right), and expansion of hoxa13b expression into the finfold domain (bottom right). A dashed yellow line in the center and bottom panels marks the boundary between the endoskeletal disc and the finfold.
References :
Freitas,
Hoxd13 contribution to the evolution of vertebrate appendages.
2012, Pubmed
Freitas,
Hoxd13 contribution to the evolution of vertebrate appendages.
2012,
Pubmed