XB-ART-47356
Genome Biol
2013 Feb 15;142:R14. doi: 10.1186/gb-2013-14-2-r14.
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Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.
Zuleger N
,
Boyle S
,
Kelly DA
,
de Las Heras JI
,
Lazou V
,
Korfali N
,
Batrakou DG
,
Randles KN
,
Morris GE
,
Harrison DJ
,
Bickmore WA
,
Schirmer EC
.
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BACKGROUND: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins that control such a mechanism in mammalian cells have yet to be widely identified. RESULTS: To search for such proteins, 23 nuclear envelope transmembrane proteins were screened for their ability to promote peripheral localization of human chromosomes in HT1080 fibroblasts. Five of these proteins had strong effects on chromosome 5, but individual proteins affected different subsets of chromosomes. The repositioning effects were reversible and the proteins with effects all exhibited highly tissue-restricted patterns of expression. Depletion of two nuclear envelope transmembrane proteins that were preferentially expressed in liver each reduced the normal peripheral positioning of chromosome 5 in liver cells. CONCLUSIONS: The discovery of nuclear envelope transmembrane proteins that can modulate chromosome position and have restricted patterns of expression may enable dissection of the functional relevance of tissue-specific patterns of radial chromosome positioning.
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Species referenced: Xenopus
Genes referenced: eif3a emd myorg nup62
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References [+] :
Aden,
Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line.
1979, Pubmed
Aden, Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. 1979, Pubmed
Albiez, Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks. 2006, Pubmed
Anderson, Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. 2009, Pubmed
Bennati, Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. 2008, Pubmed
Bolzer, Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes. 2005, Pubmed
Boyle, The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells. 2001, Pubmed
Bridger, Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts. 2000, Pubmed
Brown, Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. 2008, Pubmed
Capelson, Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. 2010, Pubmed
Chen, Nuclear envelope transmembrane proteins (NETs) that are up-regulated during myogenesis. 2006, Pubmed
Chubb, Chromatin motion is constrained by association with nuclear compartments in human cells. 2002, Pubmed
Clowney, Nuclear aggregation of olfactory receptor genes governs their monogenic expression. 2012, Pubmed
Cremer, Multicolor 3D fluorescence in situ hybridization for imaging interphase chromosomes. 2008, Pubmed
Croft, Differences in the localization and morphology of chromosomes in the human nucleus. 1999, Pubmed
Finlan, Recruitment to the nuclear periphery can alter expression of genes in human cells. 2008, Pubmed
Goldberg, The tail domain of lamin Dm0 binds histones H2A and H2B. 1999, Pubmed
Gudise, Samp1 is functionally associated with the LINC complex and A-type lamina networks. 2011, Pubmed
Guelen, Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. 2008, Pubmed
Holmer, The human lamin B receptor/sterol reductase multigene family. 1998, Pubmed
Hutten, The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. 2008, Pubmed
Höger, Interaction of Xenopus lamins A and LII with chromatin in vitro mediated by a sequence element in the carboxyterminal domain. 1991, Pubmed , Xenbase
Kalhor, Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. 2011, Pubmed
Kalverda, Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. 2010, Pubmed
Kim, Spatial genome organization during T-cell differentiation. 2004, Pubmed
King, A network of nuclear envelope membrane proteins linking centromeres to microtubules. 2008, Pubmed
Kosak, Coordinate gene regulation during hematopoiesis is related to genomic organization. 2007, Pubmed
Kumaran, A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. 2008, Pubmed
Liu, Regulation of myoblast differentiation by the nuclear envelope protein NET39. 2009, Pubmed
Makatsori, The inner nuclear membrane protein lamin B receptor forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelope. 2004, Pubmed
Malhas, Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression. 2007, Pubmed
Malik, Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope. 2010, Pubmed
Malik, Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways. 2012, Pubmed
Manilal, The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein. 1996, Pubmed
Mattout, An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity. 2011, Pubmed
Mattout-Drubezki, Dynamic interactions of nuclear lamina proteins with chromatin and transcriptional machinery. 2003, Pubmed
Meaburn, Primary laminopathy fibroblasts display altered genome organization and apoptosis. 2007, Pubmed
Mehta, Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts. 2010, Pubmed
Mehta, Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells. 2011, Pubmed
Meister, The spatial dynamics of tissue-specific promoters during C. elegans development. 2010, Pubmed
Mewborn, Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation. 2010, Pubmed
Parada, Conservation of relative chromosome positioning in normal and cancer cells. 2002, Pubmed
Parada, Tissue-specific spatial organization of genomes. 2004, Pubmed
Peric-Hupkes, Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. 2010, Pubmed
Pickersgill, Characterization of the Drosophila melanogaster genome at the nuclear lamina. 2006, Pubmed
Ragoczy, A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements. 2003, Pubmed
Rajapakse, Dynamics and control of state-dependent networks for probing genomic organization. 2011, Pubmed
Reddy, Transcriptional repression mediated by repositioning of genes to the nuclear lamina. 2008, Pubmed
Roberti, Cloning and expression of sterol Delta 14-reductase from bovine liver. 2002, Pubmed
Schirmer, Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization. 2001, Pubmed
Schirmer, Nuclear membrane proteins with potential disease links found by subtractive proteomics. 2003, Pubmed
Silve, Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae. 1998, Pubmed
Solovei, LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. 2013, Pubmed
Solovei, Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution. 2009, Pubmed
Soullam, The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal. 1993, Pubmed
Stadler, The architecture of chicken chromosome territories changes during differentiation. 2004, Pubmed
Taniura, A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones. 1995, Pubmed
Towbin, Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. 2012, Pubmed
Ulbert, The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology. 2006, Pubmed
Wiblin, Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells. 2005, Pubmed
Worman, Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation. 1988, Pubmed
Ye, Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. 1996, Pubmed
Ye, Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. 1997, Pubmed
Zink, Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei. 2004, Pubmed
Zuleger, System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics. 2011, Pubmed
Zullo, DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. 2012, Pubmed