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Figure 1. Schematic illustration of the Mcm family proteins of Xenopus laevis. The Walker A and B motifs within the Mcm family domain, and the zinc (Zn)- and arginine (R)-finger motifs are indicated. Mcm2 to Mcm7 form a hexameric complex that is essential for DNA replication. Mcm8 and Mcm9 form a dimer that is likely to be involved in HR repair.
Gambus,
Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.
2013, Pubmed,
Xenbase
Gambus,
Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.
2013,
Pubmed
,
Xenbase
Hartford,
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
2011,
Pubmed
,
Xenbase
Liu,
Ancient diversification of eukaryotic MCM DNA replication proteins.
2009,
Pubmed
Lutzmann,
MCM9 binds Cdt1 and is required for the assembly of prereplication complexes.
2008,
Pubmed
,
Xenbase
Lutzmann,
MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
2012,
Pubmed
Maiorano,
MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation.
2005,
Pubmed
,
Xenbase
Masai,
Eukaryotic chromosome DNA replication: where, when, and how?
2010,
Pubmed
Nishimura,
Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
2012,
Pubmed
