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Channels (Austin)
2013 Jan 01;73:215-20. doi: 10.4161/chan.24505.
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Recent characterizations of MscS and its homologs provide insight into the basis of ion selectivity in mechanosensitive channels.
Maksaev G
,
Haswell ES
.
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The bacterial mechanosensitive channel MscS provides an excellent model system for the study of mechanosensitivity and for investigations into the cellular response to hypoosmotic shock. Numerous studies have elucidated the structure, function and gating mechanism of Escherichia coli MscS, providing a wealth of information for the comparative analysis of MscS family members in bacteria, archaea, fungi and plants. We recently reported the electrophysiological characterization of MscS-Like (MSL)10, a MscS homolog from the model flowering plant Arabidopsis thaliana. Here we summarize our results and briefly compare MSL10 to previously described members of the MscS family. Finally, we comment on how this and other recently published studies illuminate the possible mechanisms by which ion selectivity is accomplished in this fascinating family of channels.
Arnadóttir,
Eukaryotic mechanosensitive channels.
2010,
Pubmed
Bass,
Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel.
2002,
Pubmed
Becker,
Glutamate efflux mediated by Corynebacterium glutamicum MscCG, Escherichia coli MscS, and their derivatives.
2013,
Pubmed
Berrier,
Multiple mechanosensitive ion channels from Escherichia coli, activated at different thresholds of applied pressure.
1996,
Pubmed
Booth,
Sensing bilayer tension: bacterial mechanosensitive channels and their gating mechanisms.
2011,
Pubmed
Börngen,
The properties and contribution of the Corynebacterium glutamicum MscS variant to fine-tuning of osmotic adaptation.
2010,
Pubmed
Edwards,
Pore mutations of the Escherichia coli MscS channel affect desensitization but not ionic preference.
2008,
Pubmed
Ermakov,
Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids.
2010,
Pubmed
Gamini,
Cytoplasmic domain filter function in the mechanosensitive channel of small conductance.
2011,
Pubmed
Haswell,
Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root.
2008,
Pubmed
Haswell,
Mechanosensitive channels: what can they do and how do they do it?
2011,
Pubmed
Hedrich,
Ion channels in plants.
2012,
Pubmed
Kloda,
Mechanosensitive channels in archaea.
2001,
Pubmed
Koprowski,
Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element.
2011,
Pubmed
Kung,
Mechanosensitive channels in microbes.
2010,
Pubmed
Li,
Ionic regulation of MscK, a mechanosensitive channel from Escherichia coli.
2002,
Pubmed
Li,
Identification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK.
2007,
Pubmed
Maksaev,
Expression and characterization of the bacterial mechanosensitive channel MscS in Xenopus laevis oocytes.
2011,
Pubmed
,
Xenbase
Maksaev,
MscS-Like10 is a stretch-activated ion channel from Arabidopsis thaliana with a preference for anions.
2012,
Pubmed
,
Xenbase
Malcolm,
The mechanosensitive channel of small conductance (MscS) superfamily: not just mechanosensitive channels anymore.
2012,
Pubmed
Nakayama,
Molecular and electrophysiological characterization of a mechanosensitive channel expressed in the chloroplasts of Chlamydomonas.
2007,
Pubmed
Nakayama,
Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response.
2012,
Pubmed
Noskov,
Ion selectivity in potassium channels.
2006,
Pubmed
Pivetti,
Two families of mechanosensitive channel proteins.
2003,
Pubmed
Schumann,
YbdG in Escherichia coli is a threshold-setting mechanosensitive channel with MscM activity.
2010,
Pubmed
Sotomayor,
Ion conduction through MscS as determined by electrophysiology and simulation.
2007,
Pubmed
Sukharev,
Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes.
2002,
Pubmed
Veley,
Mechanosensitive channels protect plastids from hypoosmotic stress during normal plant growth.
2012,
Pubmed
Wang,
The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.
2008,
Pubmed
Ward,
Plant ion channels: gene families, physiology, and functional genomics analyses.
2009,
Pubmed
Zhang,
Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance.
2012,
Pubmed