Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Cell Biol
2003 Oct 01;2319:6936-43. doi: 10.1128/MCB.23.19.6936-6943.2003.
Show Gene links
Show Anatomy links
Role of Plk2 (Snk) in mouse development and cell proliferation.
Ma S
,
Charron J
,
Erikson RL
.
???displayArticle.abstract??? Plk2 (Snk) is a polo-like kinase expressed at G(1) in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting. Although Plk2 is not required for postnatal growth, Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. The labyrinthine zone of the placenta is diminished in Plk2(-/-) embryos due to decreased cell proliferation. Cultured Plk2(-/-) embryonic fibroblasts grow more slowly than normal cells and show delayed entry into S phase. These data suggest a role for Plk2 in the cell cycle.
Alexandru,
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast.
2001, Pubmed
Alexandru,
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast.
2001,
Pubmed
Carmena,
Drosophila polo kinase is required for cytokinesis.
1998,
Pubmed
Charron,
Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.
1992,
Pubmed
Chase,
Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression.
1998,
Pubmed
Conn,
Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.
2000,
Pubmed
Crossin,
Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis.
1981,
Pubmed
Crossin,
Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor.
1981,
Pubmed
DeChiara,
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.
1990,
Pubmed
Descombes,
The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts.
1998,
Pubmed
,
Xenbase
Donohue,
Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase.
1995,
Pubmed
Duncan,
Cloning and characterization of Plx2 and Plx3, two additional Polo-like kinases from Xenopus laevis.
2001,
Pubmed
,
Xenbase
Efstratiadis,
Genetics of mouse growth.
1998,
Pubmed
Fantl,
Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.
1995,
Pubmed
Feng,
Polo-like kinase interacts with proteasomes and regulates their activity.
2001,
Pubmed
Fero,
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
1996,
Pubmed
Geng,
Rescue of cyclin D1 deficiency by knockin cyclin E.
1999,
Pubmed
Giroux,
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.
1999,
Pubmed
,
Xenbase
Golsteyn,
The family of polo-like kinases.
1996,
Pubmed
Hardy,
A novel role for Cdc5p in DNA replication.
1996,
Pubmed
Hoffmann,
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition.
1994,
Pubmed
Holtrich,
Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.
2000,
Pubmed
Hu,
Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints.
2001,
Pubmed
Jang,
Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.
2002,
Pubmed
,
Xenbase
Jinno,
Cdc25A is a novel phosphatase functioning early in the cell cycle.
1994,
Pubmed
Kauselmann,
The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity.
1999,
Pubmed
Kiyokawa,
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
1996,
Pubmed
Kotani,
PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.
1998,
Pubmed
Kumagai,
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.
1996,
Pubmed
,
Xenbase
Lane,
Cell-cycle control: POLO-like kinases join the outer circle.
1997,
Pubmed
,
Xenbase
Lane,
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.
1996,
Pubmed
Lee,
Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures.
1997,
Pubmed
,
Xenbase
Lin,
Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2.
2000,
Pubmed
Liu,
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.
2002,
Pubmed
Ma,
The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB.
2003,
Pubmed
Nakayama,
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.
1996,
Pubmed
Ohkura,
The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.
1995,
Pubmed
Ouyang,
Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions.
1997,
Pubmed
,
Xenbase
Qian,
Mitotic effects of a constitutively active mutant of the Xenopus polo-like kinase Plx1.
1999,
Pubmed
,
Xenbase
Qian,
Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis.
1998,
Pubmed
,
Xenbase
Qian,
The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes.
2001,
Pubmed
,
Xenbase
Ramírez-Solis,
Gene targeting in embryonic stem cells.
1993,
Pubmed
Sanchez,
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.
1999,
Pubmed
Shirayama,
The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.
1998,
Pubmed
Sicinski,
Cyclin D1 provides a link between development and oncogenesis in the retina and breast.
1995,
Pubmed
Simmons,
Identification of an early-growth-response gene encoding a novel putative protein kinase.
1992,
Pubmed
Smits,
Polo-like kinase-1 is a target of the DNA damage checkpoint.
2000,
Pubmed
Song,
A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis.
2001,
Pubmed
Sumara,
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase.
2002,
Pubmed
,
Xenbase
Sunkel,
polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.
1988,
Pubmed
Sütterlin,
Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis.
2001,
Pubmed
TODARO,
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.
1963,
Pubmed
Toczyski,
CDC5 and CKII control adaptation to the yeast DNA damage checkpoint.
1997,
Pubmed
Toyoshima-Morimoto,
Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.
2001,
Pubmed
,
Xenbase
Vortkamp,
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.
1996,
Pubmed
Wang,
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.
2002,
Pubmed
Xie,
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
2001,
Pubmed
Yu,
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney.
2002,
Pubmed
,
Xenbase
do Carmo Avides,
Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.
2001,
Pubmed