Warmflash A , Siggia ED , Brivanlou AH .

R01 GM101653 NIGMS NIH HHS

Figure 1. Schematics of simple and adaptive responses. Green lines represent ligand dynamics, and blue lines represent signaling pathway output.

Balaskas, Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. 2012, Pubmed

Balaskas, Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. 2012, Pubmed
Behar, Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways. 2007, Pubmed
François, A case study of evolutionary computation of biochemical adaptation. 2008, Pubmed
Green, Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. 1992, Pubmed , Xenbase
Hemmati-Brivanlou, A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. 1992, Pubmed , Xenbase
Massagué, Smad transcription factors. 2005, Pubmed
Tucker, The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. 2008, Pubmed
Wacker, Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation. 2004, Pubmed , Xenbase
Warmflash, Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. 2012, Pubmed , Xenbase
Wu, Tgf-beta superfamily signaling in embryonic development and homeostasis. 2009, Pubmed