Ho CY , Lammerding J .

R01 HL082792 NHLBI NIH HHS , R01 NS059348 NINDS NIH HHS

Aebi, The nuclear lamina is a meshwork of intermediate-type filaments. , Pubmed, Xenbase

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Ahmady, Identification of a novel muscle A-type lamin-interacting protein (MLIP). 2011, Pubmed
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Alaiya, Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors. 1997, Pubmed
Andrés, Role of A-type lamins in signaling, transcription, and chromatin organization. 2009, Pubmed
Arimura, Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies. 2005, Pubmed
Bank, The nuclear lamina and heterochromatin: a complex relationship. 2011, Pubmed
Bao, The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila. 2007, Pubmed
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Belt, Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrence. 2011, Pubmed
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Broers, Nuclear lamins: laminopathies and their role in premature ageing. 2006, Pubmed
Broers, Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies. 2004, Pubmed
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Capell, Mechanisms of cardiovascular disease in accelerated aging syndromes. 2007, Pubmed
Capo-chichi, Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer. 2011, Pubmed
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Chow, The nuclear envelope environment and its cancer connections. 2012, Pubmed
Chuang, Long-range directional movement of an interphase chromosome site. 2006, Pubmed
Coffinier, LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. 2010, Pubmed
Constantinescu, Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation. 2006, Pubmed
Crisp, Coupling of the nucleus and cytoplasm: role of the LINC complex. 2006, Pubmed
Cupesi, Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse. 2010, Pubmed
Dahl, Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics. 2010, Pubmed
Dahl, Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. 2006, Pubmed
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Dechat, Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. 2007, Pubmed
Dey, Nuclear margin irregularity and cancer: a review. 2009, Pubmed
Dhe-Paganon, Structure of the globular tail of nuclear lamin. 2002, Pubmed
Dittmer, The lamin protein family. 2011, Pubmed , Xenbase
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Furukawa, Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice. 1994, Pubmed
Gerhard-Herman, Mechanisms of premature vascular aging in children with Hutchinson-Gilford progeria syndrome. 2012, Pubmed
Goldberg, Filaments made from A- and B-type lamins differ in structure and organization. 2008, Pubmed , Xenbase
Goldberg, Xenopus lamin B3 has a direct role in the assembly of a replication competent nucleus: evidence from cell-free egg extracts. 1995, Pubmed , Xenbase
Gonzalez-Suarez, Loss of A-type lamins and genomic instability. 2009, Pubmed
Gonzalez-Suarez, Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. 2009, Pubmed
González, Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. 2008, Pubmed
Gotzmann, A-type lamin complexes and regenerative potential: a step towards understanding laminopathic diseases? 2006, Pubmed
Guelen, Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. 2008, Pubmed
Halaschek-Wiener, Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome. 2007, Pubmed
Hale, Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. 2008, Pubmed
Hampoelz, Nuclear mechanics in differentiation and development. 2011, Pubmed
Heald, Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. 1990, Pubmed
Heitlinger, The role of the head and tail domain in lamin structure and assembly: analysis of bacterially expressed chicken lamin A and truncated B2 lamins. 1992, Pubmed
Hernandez, Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. 2010, Pubmed , Xenbase
Holaska, Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. 2003, Pubmed
Ji, Cell nuclei spin in the absence of lamin b1. 2007, Pubmed
Johnson, A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. 2004, Pubmed
Kim, Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. 2011, Pubmed
Kolb, Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells. 2011, Pubmed
Krimm, The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy. 2002, Pubmed
Lammerding, Lamins A and C but not lamin B1 regulate nuclear mechanics. 2006, Pubmed
Lammerding, Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. 2004, Pubmed
Lattanzi, Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts. 2003, Pubmed
Lee, Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. 2007, Pubmed
Leman, Nuclear matrix proteins as biomarkers in prostate cancer. 2002, Pubmed
Levy, Nuclear size is regulated by importin α and Ntf2 in Xenopus. 2010, Pubmed , Xenbase
Liu, Genomic instability in laminopathy-based premature aging. 2005, Pubmed
Liu, Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. 2000, Pubmed
Lloyd, A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. 2002, Pubmed
Luxton, TAN lines: a novel nuclear envelope structure involved in nuclear positioning. 2011, Pubmed
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Malhas, Lamin B1 controls oxidative stress responses via Oct-1. 2009, Pubmed
Manju, Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci. 2006, Pubmed
Maraldi, Laminopathies and lamin-associated signaling pathways. 2011, Pubmed
Margalit, A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development. 2005, Pubmed
Markiewicz, Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein. 2002, Pubmed
Markiewicz, Increased solubility of lamins and redistribution of lamin C in X-linked Emery-Dreifuss muscular dystrophy fibroblasts. 2002, Pubmed
Mattout, An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity. 2011, Pubmed
McKeon, Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. , Pubmed
Mehta, Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link? 2008, Pubmed
Mekhail, The nuclear envelope in genome organization, expression and stability. 2010, Pubmed
Merideth, Phenotype and course of Hutchinson-Gilford progeria syndrome. 2008, Pubmed
Meshorer, Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging. 2008, Pubmed
Meyer, Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling. 2011, Pubmed
Moiseeva, Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells. 2011, Pubmed
Mounkes, Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice. 2005, Pubmed
Muchir, Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. 2007, Pubmed
Muchir, Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy. 2007, Pubmed
Musich, Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. 2009, Pubmed
Méjat, Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. 2009, Pubmed
Méjat, LINC complexes in health and disease. 2010, Pubmed
Naetar, Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation. 2008, Pubmed
Newport, A lamin-independent pathway for nuclear envelope assembly. 1990, Pubmed , Xenbase
Nikolova, Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. 2004, Pubmed
Nitta, Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2. 2007, Pubmed
Osouda, Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. 2005, Pubmed
Parnaik, Role of nuclear lamins in nuclear organization, cellular signaling, and inherited diseases. 2008, Pubmed
Parry, Intermediate filaments: molecular architecture, assembly, dynamics and polymorphism. 1999, Pubmed
Pekovic, Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. 2008, Pubmed
Pekovic, Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. 2007, Pubmed
Pollard, In vitro posttranslational modification of lamin B cloned from a human T-cell line. 1990, Pubmed
Prokocimer, Nuclear lamins: key regulators of nuclear structure and activities. 2009, Pubmed
Ralle, Translational control of nuclear lamin B1 mRNA during oogenesis and early development of Xenopus. 1999, Pubmed , Xenbase
Redwood, A dual role for A-type lamins in DNA double-strand break repair. 2011, Pubmed
Rodríguez, ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes. 2010, Pubmed
Rosengardten, Stem cell depletion in Hutchinson-Gilford progeria syndrome. 2011, Pubmed
Röber, Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study. 1989, Pubmed
Sakaki, Interaction between emerin and nuclear lamins. 2001, Pubmed
Sasse, A tailless Drosophila lamin Dm0 fragment reveals lateral associations of dimers. 1998, Pubmed
Sasseville, In vitro interaction of the carboxy-terminal domain of lamin A with actin. 1998, Pubmed
Scaffidi, Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. 2008, Pubmed
Schäpe, Influence of lamin A on the mechanical properties of amphibian oocyte nuclei measured by atomic force microscopy. 2009, Pubmed , Xenbase
Shevelyov, The nuclear lamina as a gene-silencing hub. 2012, Pubmed
Shimi, The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. 2008, Pubmed
Shumaker, The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication. 2008, Pubmed , Xenbase
Simon, Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail. 2010, Pubmed
Simon, The nucleoskeleton as a genome-associated dynamic 'network of networks'. 2011, Pubmed
Smythe, Incorporation of the nuclear pore basket protein nup153 into nuclear pore structures is dependent upon lamina assembly: evidence from cell-free extracts of Xenopus eggs. 2000, Pubmed , Xenbase
Spann, Disruption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis. 1997, Pubmed , Xenbase
Stadelmann, Repression of nuclear lamin A and C gene expression in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells. 1990, Pubmed
Stehbens, Smooth muscle cell depletion and collagen types in progeric arteries. 2001, Pubmed
Stuurman, Nuclear lamins: their structure, assembly, and interactions. 1998, Pubmed
Sullivan, Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. 1999, Pubmed
Sun, Circulating Lamin B1 (LMNB1) biomarker detects early stages of liver cancer in patients. 2010, Pubmed
Verstraeten, Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. 2008, Pubmed
Verstraeten, The nuclear envelope, a key structure in cellular integrity and gene expression. 2007, Pubmed
Wang, Differential protein mapping of ovarian serous adenocarcinomas: identification of potential markers for distinct tumor stage. 2009, Pubmed
Wang, [A lamin-like protein gene is down-regulated in human gastric cancer]. 2003, Pubmed
Warren, Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging. 2011, Pubmed
Willis, Lamin A/C is a risk biomarker in colorectal cancer. 2008, Pubmed
Willis, Lamin A: a putative colonic epithelial stem cell biomarker which identifies colorectal tumours with a more aggressive phenotype. 2008, Pubmed
Wilson, Lamin-binding Proteins. 2010, Pubmed
Wilson, The nuclear envelope at a glance. 2010, Pubmed
Worman, Nuclear lamins and laminopathies. 2012, Pubmed
Worman, Laminopathies and the long strange trip from basic cell biology to therapy. 2009, Pubmed
Wu, Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma. 2009, Pubmed
Zhong, Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C. 2005, Pubmed
Zwerger, Nuclear mechanics in disease. 2011, Pubmed
di Masi, The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation. 2008, Pubmed