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J Comput Neurosci
2011 Nov 01;313:615-23. doi: 10.1007/s10827-011-0329-9.
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Mechanism of conduction block in amphibian myelinated axon induced by biphasic electrical current at ultra-high frequency.
Tai C
,
Guo D
,
Wang J
,
Roppolo JR
,
de Groat WC
.
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The mechanism of axonal conduction block induced by ultra-high frequency (≥ 20 kHz) biphasic electrical current was investigated using a lumped circuit model of the amphibian myelinated axon based on Frankenhaeuser-Huxley (FH) equations. The ultra-high frequency stimulation produces constant activation of both sodium and potassium channels at the axonal node under the block electrode causing the axonal conduction block. This blocking mechanism is different from the mechanism when the stimulation frequency is between 4 kHz and 10 kHz, where only the potassium channel is constantly activated. The minimal stimulation intensity required to induce a conduction block increases as the stimulation frequency increases. The results from this simulation study are useful to guide future animal experiments to reveal the different mechanisms underlying nerve conduction block induced by high-frequency biphasic electrical current.
Bhadra,
High-frequency electrical conduction block of mammalian peripheral motor nerve.
2005, Pubmed
Bhadra,
High-frequency electrical conduction block of mammalian peripheral motor nerve.
2005,
Pubmed
Bhadra,
Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons.
2007,
Pubmed
Bikson,
Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices.
2001,
Pubmed
Bowman,
Response of single alpha motoneurons to high-frequency pulse trains. Firing behavior and conduction block phenomenon.
1986,
Pubmed
Bromm,
Spike frequency of the nodal membrane generated by high-frequency alternating current.
1975,
Pubmed
Chiu,
A quantitative description of membrane currents in rabbit myelinated nerve.
1979,
Pubmed
FRANKENHAEUSER,
THE ACTION POTENTIAL IN THE MYELINATED NERVE FIBER OF XENOPUS LAEVIS AS COMPUTED ON THE BASIS OF VOLTAGE CLAMP DATA.
1964,
Pubmed
,
Xenbase
Gaunt,
Transcutaneously coupled, high-frequency electrical stimulation of the pudendal nerve blocks external urethral sphincter contractions.
2009,
Pubmed
Gerges,
Frequency- and amplitude-transitioned waveforms mitigate the onset response in high-frequency nerve block.
2010,
Pubmed
HODGKIN,
A quantitative description of membrane current and its application to conduction and excitation in nerve.
1952,
Pubmed
Jensen,
Suppression of axonal conduction by sinusoidal stimulation in rat hippocampus in vitro.
2007,
Pubmed
Joseph,
Unmyelinated Aplysia nerves exhibit a nonmonotonic blocking response to high-frequency stimulation.
2009,
Pubmed
Lian,
Local suppression of epileptiform activity by electrical stimulation in rat hippocampus in vitro.
2003,
Pubmed
Liu,
The role of slow potassium current in nerve conduction block induced by high-frequency biphasic electrical current.
2009,
Pubmed
Loeb,
Neural prosthetic interfaces with the nervous system.
1989,
Pubmed
Nashold,
Long-term pain control by direct peripheral-nerve stimulation.
1982,
Pubmed
Rattay,
Modeling axon membranes for functional electrical stimulation.
1993,
Pubmed
Roth,
Mechanisms for electrical stimulation of excitable tissue.
1994,
Pubmed
Schwarz,
Action potentials and membrane currents in the human node of Ranvier.
1995,
Pubmed
Schwarz,
Na currents and action potentials in rat myelinated nerve fibres at 20 and 37 degrees C.
1987,
Pubmed
TANNER,
Reversible blocking of nerve conduction by alternating-current excitation.
1962,
Pubmed
Tai,
Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve.
2004,
Pubmed
Tai,
Response of external urethral sphincter to high frequency biphasic electrical stimulation of pudendal nerve.
2005,
Pubmed
Tai,
Simulation analysis of conduction block in unmyelinated axons induced by high-frequency biphasic electrical currents.
2005,
Pubmed
Tai,
Simulation of nerve block by high-frequency sinusoidal electrical current based on the Hodgkin-Huxley model.
2005,
Pubmed
Tai,
Influence of temperature on pudendal nerve block induced by high frequency biphasic electrical current.
2008,
Pubmed
Wang,
Influence of frequency and temperature on the mechanisms of nerve conduction block induced by high-frequency biphasic electrical current.
2008,
Pubmed
Williamson,
Localized electrical nerve blocking.
2005,
Pubmed
Zhang,
Simulation analysis of conduction block in myelinated axons induced by high-frequency biphasic rectangular pulses.
2006,
Pubmed
Zhang,
Mechanism of nerve conduction block induced by high-frequency biphasic electrical currents.
2006,
Pubmed
