XB-ART-45523
Dev Biol
2012 Jun 01;3661:55-63. doi: 10.1016/j.ydbio.2012.02.038.
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Specification of neural crest into sensory neuron and melanocyte lineages.
Pavan WJ
,
Raible DW
.
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Elucidating the mechanisms by which multipotent cells differentiate into distinct lineages is a common theme underlying developmental biology investigations. Progress has been made in understanding some of the essential factors and pathways involved in the specification of different lineages from the neural crest. These include gene regulatory networks involving transcription factor hierarchies and input from signaling pathways mediated from environmental cues. In this review, we examine the mechanisms for two lineages that are derived from the neural crest, peripheral sensory neurons and melanocytes. Insights into the specification of these cell types may reveal common themes in the specification processes that occur throughout development.
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References [+] :
Adameyko,
Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.
2012, Pubmed
Adameyko, Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. 2012, Pubmed
Adameyko, Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. 2009, Pubmed
Andermann, Neurogenin1 defines zebrafish cranial sensory ganglia precursors. 2002, Pubmed
Aoki, Sox10 regulates the development of neural crest-derived melanocytes in Xenopus. 2003, Pubmed , Xenbase
Averill, Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. 1995, Pubmed
Bennett, A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. 1998, Pubmed
Bertrand, Proneural genes and the specification of neural cell types. 2002, Pubmed
Blader, The activity of neurogenin1 is controlled by local cues in the zebrafish embryo. 1997, Pubmed , Xenbase
Botchkareva, SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. 2001, Pubmed
Britsch, The transcription factor Sox10 is a key regulator of peripheral glial development. 2001, Pubmed
Cable, Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse. 1995, Pubmed
Camp, Tyrosinase gene expression in zebrafish embryos. 2001, Pubmed
Campero, Unmyelinated afferents in human skin and their responsiveness to low temperature. 2010, Pubmed
Carr, Proliferative and degenerative events in the early development of chick dorsal root ganglia. II. Responses to altered peripheral fields. 1978, Pubmed
Carreira, Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. 2006, Pubmed
Chen, Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. 2006, Pubmed
Chen, Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord. 2006, Pubmed
Cheung, The transcriptional control of trunk neural crest induction, survival, and delamination. 2005, Pubmed
Cheung, Neural crest development is regulated by the transcription factor Sox9. 2003, Pubmed
Cornell, Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function. 2002, Pubmed
Crowley, Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. 1994, Pubmed
Curran, Foxd3 controls melanophore specification in the zebrafish neural crest by regulation of Mitf. 2009, Pubmed
Delmas, Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. 2007, Pubmed
Dhaka, Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. 2008, Pubmed
Dong, A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. 2001, Pubmed
Dorsky, Control of neural crest cell fate by the Wnt signalling pathway. 1998, Pubmed
Dorsky, Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway. 2000, Pubmed
Dunn, WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action. 2005, Pubmed
Dunn, Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. 2000, Pubmed
Dupin, Development of melanocyte precursors from the vertebrate neural crest. 2003, Pubmed
Dupin, Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor. 2000, Pubmed
Dutton, Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. 2001, Pubmed
Dykes, Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. 2010, Pubmed
Dykes, Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. 2011, Pubmed
Eng, POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. 2007, Pubmed
Eng, Coordinated regulation of gene expression by Brn3a in developing sensory ganglia. 2004, Pubmed
Eng, Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice. 2001, Pubmed
Erickson, Descriptive and experimental analysis of the dispersion of neural crest cells along the dorsolateral path and their entry into ectoderm in the chick embryo. 1992, Pubmed
Ernfors, Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. 1994, Pubmed
Ernsberger, The role of GDNF family ligand signalling in the differentiation of sympathetic and dorsal root ganglion neurons. 2008, Pubmed
Ernsberger, Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia. 2009, Pubmed
Fariñas, Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. 1998, Pubmed
Fariñas, Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. 1994, Pubmed
Fedtsova, Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors. 1995, Pubmed
Fode, The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. 1998, Pubmed
García-Castro, Ectodermal Wnt function as a neural crest inducer. 2002, Pubmed
Ge, Coupling of cell migration with neurogenesis by proneural bHLH factors. 2006, Pubmed
Genç, A chemoattractant role for NT-3 in proprioceptive axon guidance. 2004, Pubmed
George, Nociceptive sensory neurons derive from contralaterally migrating, fate-restricted neural crest cells. 2007, Pubmed
George, Patterned assembly and neurogenesis in the chick dorsal root ganglion. 2010, Pubmed
Greenhill, An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. 2011, Pubmed
Greenwood, Identification of dividing, determined sensory neuron precursors in the mammalian neural crest. 1999, Pubmed
Guo, An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 2011, Pubmed , Xenbase
HAMBURGER, Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. 1949, Pubmed
HAMBURGER, Experimental analysis of the dual origin of the trigeminal ganglion in the chick embryo. 1961, Pubmed
Han, Intracellular signaling and the origins of the sensations of itch and pain. 2011, Pubmed
Hand, Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. 2005, Pubmed
Hari, Lineage-specific requirements of beta-catenin in neural crest development. 2002, Pubmed
Harris, Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition. 2008, Pubmed
Helms, Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons. 2005, Pubmed
Henion, trkC-mediated NT-3 signaling is required for the early development of a subpopulation of neurogenic neural crest cells. 1995, Pubmed
Hjerling-Leffler, Emergence of functional sensory subtypes as defined by transient receptor potential channel expression. 2007, Pubmed
Hjerling-Leffler, The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. 2005, Pubmed
Hodgkinson, Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. 1993, Pubmed
Hong, Sox proteins and neural crest development. 2005, Pubmed
Honoré, Sox10 is required for the early development of the prospective neural crest in Xenopus embryos. 2003, Pubmed , Xenbase
Hosoda, Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. 1994, Pubmed
Hou, Interspecies difference in the regulation of melanocyte development by SOX10 and MITF. 2006, Pubmed
Hou, Cell-autonomous and cell non-autonomous signaling through endothelin receptor B during melanocyte development. 2004, Pubmed
Hou, Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF. 2000, Pubmed
Huang, POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. 1999, Pubmed
Hughes, A helix-loop-helix transcription factor-like gene is located at the mi locus. 1993, Pubmed
Ikeya, Wnt signalling required for expansion of neural crest and CNS progenitors. 1997, Pubmed
Inoue, The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. 2007, Pubmed
Inoue, Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. 2002, Pubmed
Ito, Removal of stem cell factor or addition of monoclonal anti-c-KIT antibody induces apoptosis in murine melanocyte precursors. 1999, Pubmed
Ito, Oncogenic potential of the RUNX gene family: 'overview'. 2004, Pubmed
Jin, Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo. 2001, Pubmed
Johnston, A radioautographic study of the migration and fate of cranial neural crest cells in the chick embryo. 1966, Pubmed
Kageyama, Roles of bHLH genes in neural stem cell differentiation. 2005, Pubmed
Kashiba, Coexpression of preprotachykinin-A, alpha-calcitonin gene-related peptide, somatostatin, and neurotrophin receptor family messenger RNAs in rat dorsal root ganglion neurons. 1996, Pubmed
Kelsh, Stripes and belly-spots -- a review of pigment cell morphogenesis in vertebrates. 2009, Pubmed
Kelsh, The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives. 2000, Pubmed
Kikuchi, Selective activation mechanisms of Wnt signaling pathways. 2009, Pubmed
Kitao, Neurogenesis of subpopulations of rat lumbar dorsal root ganglion neurons including neurons projecting to the dorsal column nuclei. 1996, Pubmed
Klein, Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. 1994, Pubmed
Kos, The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. 2001, Pubmed
Kramer, A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. 2006, Pubmed
Krispin, Evidence for a dynamic spatiotemporal fate map and early fate restrictions of premigratory avian neural crest. 2010, Pubmed
LaBonne, Induction and patterning of the neural crest, a stem cell-like precursor population. 1998, Pubmed , Xenbase
Lahav, Endothelin 3 selectively promotes survival and proliferation of neural crest-derived glial and melanocytic precursors in vitro. 1998, Pubmed
Lahav, Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. 1996, Pubmed
Lane, Association of megacolon with a new dominant spotting gene (Dom) in the mouse. 1984, Pubmed
Lanier, Brn3a target gene recognition in embryonic sensory neurons. 2007, Pubmed
Lanier, Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. 2009, Pubmed
Lawson, Development of mouse dorsal root ganglia: an autoradiographic and quantitative study. 1979, Pubmed
Lecoin, Steel and c-kit in the development of avian melanocytes: a study of normally pigmented birds and of the hyperpigmented mutant silky fowl. 1995, Pubmed
Lee, The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors. 2003, Pubmed
Lee, Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. 2004, Pubmed
Lei, Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons. 2006, Pubmed
Levanon, Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. 2001, Pubmed
Levanon, The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. 2002, Pubmed
Lewis, Reiterated Wnt signaling during zebrafish neural crest development. 2004, Pubmed
Li, Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons. 2010, Pubmed
Li, The functional organization of cutaneous low-threshold mechanosensory neurons. 2011, Pubmed
Lister, nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate. 1999, Pubmed
Liu, Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. 2008, Pubmed
Lo, Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. 2002, Pubmed
Loring, Neural crest cell migratory pathways in the trunk of the chick embryo. 1987, Pubmed
Luciani, Biological and mathematical modeling of melanocyte development. 2011, Pubmed
Luo, A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. 2007, Pubmed
Luo, Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. 2009, Pubmed
Luo, Molecular identification of distinct neurogenic and melanogenic neural crest sublineages. 2003, Pubmed
Ma, Identification of neurogenin, a vertebrate neuronal determination gene. 1996, Pubmed , Xenbase
Ma, neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. 1998, Pubmed , Xenbase
Ma, Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. 1999, Pubmed , Xenbase
Ma, Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. 2003, Pubmed
Ma, Labeled lines meet and talk: population coding of somatic sensations. 2010, Pubmed
Mackenzie, Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. 1997, Pubmed
Marmigère, The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons. 2006, Pubmed
Maro, Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS. 2004, Pubmed
Mayer, The migratory pathway of neural crest cells into the skin of mouse embryos. 1973, Pubmed
McEvilly, Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. 1996, Pubmed
McGraw, Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1. 2008, Pubmed
McKeown, Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation. 2005, Pubmed
McMahon, Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. 1994, Pubmed
Mellgren, A requirement for kit in embryonic zebrafish melanocyte differentiation is revealed by melanoblast delay. 2004, Pubmed
Miller, Timing is everything: making neurons versus glia in the developing cortex. 2007, Pubmed
Minichiello, Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. 1995, Pubmed
Miyamura, Regulation of human skin pigmentation and responses to ultraviolet radiation. 2007, Pubmed
Mochii, Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell. 1998, Pubmed
Molliver, Nerve growth factor receptor TrkA is down-regulated during postnatal development by a subset of dorsal root ganglion neurons. 1997, Pubmed
Molliver, IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. 1997, Pubmed
Monsoro-Burq, Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. 2005, Pubmed , Xenbase
Moqrich, Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. 2004, Pubmed
Morrison, Neuronal differentiation: proneural genes inhibit gliogenesis. 2001, Pubmed
Mu, Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia. 1993, Pubmed
Nakayama, Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently. 1998, Pubmed
Nieto, Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. 2001, Pubmed
Nishikawa, In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development. 1991, Pubmed
Noden, The control of avian cephalic neural crest cytodifferentiation. II. Neural tissues. 1978, Pubmed
Opdecamp, Endothelin signalling in the development of neural crest-derived melanocytes. 1998, Pubmed
Opdecamp, Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. 1997, Pubmed
Osawa, Molecular characterization of melanocyte stem cells in their niche. 2005, Pubmed
Parras, Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. 2002, Pubmed
Passeron, SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentation. 2007, Pubmed
Patel, Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. 2003, Pubmed
Patel, Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. 2000, Pubmed
Pavan, Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes. 1994, Pubmed
Perez, Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo. 1999, Pubmed , Xenbase
Qin, Long-range activation of Sox9 in Odd Sex (Ods) mice. 2004, Pubmed
RAWLES, Origin of pigment cells from the neural crest in the mouse embryo. 1947, Pubmed
RAWLES, Origin of melanophores and their role in development of color patterns in vertebrates. 1948, Pubmed
Raible, Segregation and early dispersal of neural crest cells in the embryonic zebrafish. 1992, Pubmed
Raible, Restriction of neural crest cell fate in the trunk of the embryonic zebrafish. 1994, Pubmed
Rawls, Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival. 2003, Pubmed
Reedy, The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube. 1998, Pubmed
Reedy, Specification and migration of melanoblasts at the vagal level and in hyperpigmented Silkie chickens. 1998, Pubmed
Reid, Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. 1996, Pubmed
Rifkin, Dynamic expression of neurotrophin receptors during sensory neuron genesis and differentiation. 2000, Pubmed
Ross, Basic helix-loop-helix factors in cortical development. 2003, Pubmed
Schepers, Thermoreceptors and thermosensitive afferents. 2010, Pubmed
Serbedzija, Pathways of trunk neural crest cell migration in the mouse embryo as revealed by vital dye labelling. 1990, Pubmed
Shibata, Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes. 2010, Pubmed
Shin, The temporal requirement for endothelin receptor-B signalling during neural crest development. 1999, Pubmed
Smeyne, Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. 1994, Pubmed
Sommer, Generation of melanocytes from neural crest cells. 2011, Pubmed
Sommer, neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. 1996, Pubmed , Xenbase
Southard-Smith, Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. 1998, Pubmed
Spokony, The transcription factor Sox9 is required for cranial neural crest development in Xenopus. 2002, Pubmed , Xenbase
Stucky, Isolectin B(4)-positive and -negative nociceptors are functionally distinct. 1999, Pubmed
Sun, A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. 2008, Pubmed
Sun, Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. 2001, Pubmed , Xenbase
Tachibana, Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics. 1996, Pubmed
Takeda, Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a. 2000, Pubmed
Taylor, SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation. 2005, Pubmed , Xenbase
Teng, Requirement for Foxd3 in the maintenance of neural crest progenitors. 2008, Pubmed
Tessarollo, Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons. 1994, Pubmed
Thomas, The making of a melanocyte: the specification of melanoblasts from the neural crest. 2008, Pubmed
Thomas, FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism. 2009, Pubmed
Trentin, Self-renewal capacity is a widespread property of various types of neural crest precursor cells. 2004, Pubmed
Vallbo, Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. 1979, Pubmed
Wang, Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. 2011, Pubmed
Weintraub, The myoD gene family: nodal point during specification of the muscle cell lineage. 1991, Pubmed
Weston, Sequential segregation and fate of developmentally restricted intermediate cell populations in the neural crest lineage. 1991, Pubmed
Weston, The migration and differentiation of neural crest cells. 1970, Pubmed
Whiteman, The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. 2011, Pubmed
Wilson, Neural crest cell lineage segregation in the mouse neural tube. 2004, Pubmed
Woolf, Nociceptors--noxious stimulus detectors. 2007, Pubmed
Wright, Neurotrophin receptor mRNA expression defines distinct populations of neurons in rat dorsal root ganglia. 1995, Pubmed
Xiang, Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. 1996, Pubmed
Yan, A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. 2005, Pubmed
Yanfeng, Wnt-frizzled signaling in the induction and differentiation of the neural crest. 2003, Pubmed
Yoshida, Distinct stages of melanocyte differentiation revealed by anlaysis of nonuniform pigmentation patterns. 1996, Pubmed
Yoshikawa, Runx1 selectively regulates cell fate specification and axonal projections of dorsal root ganglion neurons. 2007, Pubmed
Zaret, Pioneer transcription factors: establishing competence for gene expression. 2011, Pubmed
Zhang, Expression of trk and neurotrophin mRNA in dorsal root and sympathetic ganglia of the quail during development. 1994, Pubmed
Zirlinger, Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. 2002, Pubmed
Zwick, Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. 2002, Pubmed
van Amerongen, Towards an integrated view of Wnt signaling in development. 2009, Pubmed