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Adult newts are able to regenerate their retina and lens after injury or complete removal through transdifferentiation of the pigmented epithelial tissues of the eye. This process needs to be tightly controlled, and several different mechanisms are likely to be recruited for this function. The Na(+)/K(+) ATPase is a transmembrane protein that establishes electrochemical gradients through the transport of Na(+) and K(+) and has been implicated in the modulation of key cellular processes such as cell division, migration and adhesion. Even though it is expressed in all cells, its isoform composition varies with cell type and is tightly controlled during development and regeneration. In the present study we characterize the expression pattern of Na(+)/K(+) ATPase alpha1 in the adult newt eye and during the process of lens and retina regeneration. We show that this isoform is up-regulated in undifferentiated cells during transdifferentiation. Such change in composition could be one of the mechanisms that newt cells utilize to modulate this process.
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???displayArticle.pmcLink???PMC2693948 ???displayArticle.link???Exp Eye Res ???displayArticle.grants???[+]
Adams,
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration.
2007, Pubmed,
Xenbase
Adams,
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration.
2007,
Pubmed
,
Xenbase
Arteaga,
Regeneration influences expression of the Na+, K+-atpase subunit isoforms in the rat peripheral nervous system.
2004,
Pubmed
Aydemir-Koksoy,
Ouabain-induced signaling and vascular smooth muscle cell proliferation.
2001,
Pubmed
Bailey,
Regulation of vertebrate eye development by Rx genes.
2004,
Pubmed
,
Xenbase
Barwe,
Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.
2005,
Pubmed
Brockes,
Plasticity and reprogramming of differentiated cells in amphibian regeneration.
2002,
Pubmed
Cameron,
Neurons and astroglia express distinct subsets of Na,K-ATPase alpha and beta subunits.
1994,
Pubmed
Chen,
Regulation of inositol 1,4,5-trisphosphate receptor-mediated calcium release by the Na/K-ATPase in cultured renal epithelial cells.
2008,
Pubmed
Cheon,
Choline acetyltransferase and acetylcholinesterase in the normal, developing and regenerating newt retinas.
1999,
Pubmed
Chittum,
Rabbit beta-globin is extended beyond its UGA stop codon by multiple suppressions and translational reading gaps.
1998,
Pubmed
Del Rio-Tsonis,
Eye regeneration at the molecular age.
2003,
Pubmed
,
Xenbase
Delamere,
Expression, regulation and function of Na,K-ATPase in the lens.
2004,
Pubmed
Drummond,
Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function.
1998,
Pubmed
Eguchi,
Cellular and molecular background of wolffian lens regeneration.
1988,
Pubmed
Eng,
Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.
1994,
Pubmed
Farman,
Localization of alpha-isoforms of Na(+)-K(+)-ATPase in rat kidney by in situ hybridization.
1991,
Pubmed
Fischer,
Transdifferentiation of pigmented epithelial cells: a source of retinal stem cells?
2001,
Pubmed
Flügel,
Presence and distribution of Na+/K+-ATPase in the ciliary epithelium of the rabbit.
1988,
Pubmed
Ghosh,
Cellular distribution and differential gene expression of the three alpha subunit isoforms of the Na,K-ATPase in the ocular ciliary epithelium.
1990,
Pubmed
Gilmore-Hebert,
Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells.
1989,
Pubmed
Grogg,
BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration.
2005,
Pubmed
Haas,
Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase.
2000,
Pubmed
Haas,
Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases.
2002,
Pubmed
Habiba,
Embryonic stem cells: a model to study Na,K-ATPase isoform expression during development.
2000,
Pubmed
Haynes,
Retina repair, stem cells and beyond.
2004,
Pubmed
He,
The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility.
2001,
Pubmed
Hlivko,
The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.
2006,
Pubmed
Imokawa,
Analysis of a unique molecule responsible for regeneration and stabilization of differentiated state of tissue cells.
1992,
Pubmed
Kometiani,
Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases.
1998,
Pubmed
Levin,
Large-scale biophysics: ion flows and regeneration.
2007,
Pubmed
Li,
The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades.
2009,
Pubmed
Liang,
Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay.
2006,
Pubmed
Liu,
Ouabain interaction with cardiac Na+/K+-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca2+ concentrations.
2000,
Pubmed
Liu,
Na,K-ATPase alpha3 subunit in the goldfish retina during optic nerve regeneration.
2002,
Pubmed
Madhavan,
The role of Pax-6 in lens regeneration.
2006,
Pubmed
Makar'ev,
[Expression of regulatory homeobox genes during retina regeneration in adult newts].
2002,
Pubmed
Markitantova,
[Analysis of the expression pattern of regulatory genes Pax6, Prox1, and Six3 during regeneration of eye structures in the newt].
2004,
Pubmed
Martin-Vasallo,
Expression of Na,K-ATPase alpha subunit isoforms in the human ciliary body and cultured ciliary epithelial cells.
1989,
Pubmed
Mitashov,
Mechanisms of retina regeneration in urodeles.
1996,
Pubmed
Mitashov,
Retinal regeneration in amphibians.
1997,
Pubmed
Mobasheri,
Expression and cellular localization of Na,K-ATPase isoforms in the rat ventral prostate.
2003,
Pubmed
Molday,
Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex.
2007,
Pubmed
Mori,
Immunocytochemical localization of Na/K-ATPase in the isolated ciliary epithelial bilayer of the rabbit.
1991,
Pubmed
Moseley,
Genetic profiling reveals global changes in multiple biological pathways in the hearts of Na, K-ATPase alpha 1 isoform haploinsufficient mice.
2005,
Pubmed
Nakamura,
Evidence for Notch signaling involvement in retinal regeneration of adult newt.
2007,
Pubmed
Okami,
Quantitative immunocytochemical localization of Na+,K+-ATPase in rat ciliary epithelial cells.
1989,
Pubmed
Orlowski,
Tissue-specific and developmental regulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs.
1988,
Pubmed
Raymond,
How the neural retina regenerates.
2000,
Pubmed
Reh,
Transdifferentiation and retinal regeneration.
1995,
Pubmed
Reid,
Wound healing in rat cornea: the role of electric currents.
2005,
Pubmed
Seegers,
Activation of signal-transduction mechanisms may underlie the therapeutic effects of an applied electric field.
2001,
Pubmed
Song,
Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo.
2002,
Pubmed
Song,
Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo.
2004,
Pubmed
Sánchez Alvarado,
Bridging the regeneration gap: genetic insights from diverse animal models.
2006,
Pubmed
Tian,
Binding of Src to Na+/K+-ATPase forms a functional signaling complex.
2006,
Pubmed
Tsonis,
A novel role of the hedgehog pathway in lens regeneration.
2004,
Pubmed
Tsonis,
Regeneration in vertebrates.
2000,
Pubmed
Tumlin,
Expression of Na-K-ATPase alpha- and beta-subunit mRNA and protein isoforms in the rat nephron.
1994,
Pubmed
Vergara,
CNS regeneration: a morphogen's tale.
2005,
Pubmed
Wetzel,
Cellular and subcellular specification of Na,K-ATPase alpha and beta isoforms in the postnatal development of mouse retina.
1999,
Pubmed
Woo,
Sperm motility is dependent on a unique isoform of the Na,K-ATPase.
2000,
Pubmed
Woo,
Roles of the Na,K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility.
2002,
Pubmed
Xie,
Na(+)/K(+)-ATPase as a signal transducer.
2002,
Pubmed
Zhang,
Fiber specific differential phosphorylation of the alpha1-subunit of the Na(+),K (+)-ATPase in rat skeletal muscle: the effect of aging.
2007,
Pubmed
