XB-ART-44951
Dev Neurobiol
2012 Apr 01;724:465-74. doi: 10.1002/dneu.20920.
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Reserve pool neuron transmitter respecification: Novel neuroplasticity.
Dulcis D
,
Spitzer NC
.
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The identity of the neurotransmitters expressed by neurons has been thought to be fixed and immutable, but recent studies demonstrate that changes in electrical activity can rapidly and reversibly reconfigure the transmitters and corresponding transmitter receptors that neurons express. Induction of transmitter expression can be achieved by selective activation of afferents recruited by a physiological range of sensory input. Strikingly, neurons acquiring an additional transmitter project to appropriate targets prior to transmitter respecification in some cases, indicating the presence of reserve pools of neurons that can boost circuit function. We discuss the evidence for such reserve pools, their likely locations and ways to test for their existence, and the potential clinical value of such circuit-specific neurotransmitter respecification for treatments of neurological disorders.
???displayArticle.pubmedLink??? 21595049
???displayArticle.pmcLink??? PMC3192250
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???displayArticle.grants??? [+]
MH74702 NIMH NIH HHS, NS15918 NINDS NIH HHS , R01 MH074702-04 NIMH NIH HHS, R01 MH074702-05 NIMH NIH HHS, R01 NS015918-28 NINDS NIH HHS , R01 NS015918-29 NINDS NIH HHS , R01 NS015918-30 NINDS NIH HHS , R01 NS015918-31 NINDS NIH HHS , R01 NS015918-32 NINDS NIH HHS , R01 NS015918-33 NINDS NIH HHS , R01 NS057690-03 NINDS NIH HHS
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