XB-ART-44946
Wiley Interdiscip Rev RNA
2011 Jan 01;25:686-99. doi: 10.1002/wrna.85.
Show Gene links
Show Anatomy links
Emerging roles for the Ro 60-kDa autoantigen in noncoding RNA metabolism.
Sim S
,
Wolin SL
.
???displayArticle.abstract???
All cells contain an enormous variety of ribonucleoprotein (RNP) complexes that function in diverse processes. Although the mechanisms by which many of these RNPs contribute to cell metabolism are well understood, the roles of others are only now beginning to be revealed. A member of this latter category, the Ro 60-kDa protein and its associated noncoding Y RNAs, was discovered because the protein component is a frequent target of the autoimmune response in patients with the rheumatic diseases systemic lupus erythematosus and Sjögren's syndrome. Recent studies have shown that Ro is ring shaped, binds the single-stranded ends of misfolded noncoding RNAs in its central cavity, and may function in noncoding RNA quality control. Although Ro is not present in yeast, many bacterial genomes contain potential Ro orthologs. In the radiation-resistant eubacterium Deinococcus radiodurans, the Ro ortholog functions with exoribonucleases during stress-induced changes in RNA metabolism. Moreover, in both D. radiodurans and animal cells, Ro is involved in the response to multiple types of environmental stress. Finally, Y RNAs can influence the subcellular location of Ro, inhibit access of the central cavity to other RNAs, and may also act as binding sites for proteins that influence Ro function. WIREs RNA 2011 2 686-699 DOI: 10.1002/wrna.85 For further resources related to this article, please visit the WIREs website.
???displayArticle.pubmedLink??? 21823229
???displayArticle.pmcLink??? PMC3154076
???displayArticle.link??? Wiley Interdiscip Rev RNA
???displayArticle.grants??? [+]
5R01GM048410 NIGMS NIH HHS , R01 GM048410-17 NIGMS NIH HHS , R01 GM073863-04 NIGMS NIH HHS , R01 GM073863-04S1 NIGMS NIH HHS , R01GM073863 NIGMS NIH HHS , R01 GM073863 NIGMS NIH HHS , R01 GM048410 NIGMS NIH HHS
References [+] :
Alspaugh,
Antibodies to cellular antigens in Sjögren's syndrome.
1975, Pubmed
Alspaugh, Antibodies to cellular antigens in Sjögren's syndrome. 1975, Pubmed
Arraiano, The critical role of RNA processing and degradation in the control of gene expression. 2010, Pubmed
Avalos, Regulation of autoreactive B cell responses to endogenous TLR ligands. 2010, Pubmed
Ben-Chetrit, A 52-kD protein is a novel component of the SS-A/Ro antigenic particle. 1988, Pubmed
Ben-Chetrit, Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen. 1989, Pubmed
Boire, Purification of antigenically intact Ro ribonucleoproteins; biochemical and immunological evidence that the 52-kD protein is not a Ro protein. 1995, Pubmed
Bonneau, The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation. 2009, Pubmed
Bouffard, Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. 2000, Pubmed
Buyon, Anti-Ro/SSA antibodies and congenital heart block: necessary but not sufficient. 2001, Pubmed
Chen, Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation. 2000, Pubmed
Chen, The Ro autoantigen binds misfolded U2 small nuclear RNAs and assists mammalian cell survival after UV irradiation. 2003, Pubmed , Xenbase
Chen, An ortholog of the Ro autoantigen functions in 23S rRNA maturation in D. radiodurans. 2007, Pubmed
Chenna, Multiple sequence alignment with the Clustal series of programs. 2003, Pubmed
Choudhary, Lysine acetylation targets protein complexes and co-regulates major cellular functions. 2009, Pubmed
Clancy, Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block. 2010, Pubmed
Clark, Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythmatosus. 1969, Pubmed
Deutscher, Molecular analysis of the 60-kDa human Ro ribonucleoprotein. 1988, Pubmed
Fabini, The heterogeneous nuclear ribonucleoproteins I and K interact with a subset of the ro ribonucleoprotein-associated Y RNAs in vitro and in vivo. 2001, Pubmed
Farris, Y3 is the most conserved small RNA component of Ro ribonucleoprotein complexes in vertebrate species. 1995, Pubmed , Xenbase
Farris, Conserved features of Y RNAs revealed by automated phylogenetic secondary structure analysis. 1999, Pubmed
Fouraux, Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes. 2002, Pubmed
Fuchs, Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen. 2006, Pubmed , Xenbase
Gendron, Heterogeneity of human Ro ribonucleoproteins (RNPS): nuclear retention of Ro RNPS containing the human hY5 RNA in human and mouse cells. 2001, Pubmed
Green, Binding of the 60-kDa Ro autoantigen to Y RNAs: evidence for recognition in the major groove of a conserved helix. 1998, Pubmed , Xenbase
Hafner, Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. 2010, Pubmed
Hall, Interaction of N-terminal domain of U1A protein with an RNA stem/loop. 1992, Pubmed
Hendrick, Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells. 1981, Pubmed
Hernández-Molina, The meaning of anti-Ro and anti-La antibodies in primary Sjögren's syndrome. 2011, Pubmed
Hoffmann, Nucleic acid-associated autoantigens: pathogenic involvement and therapeutic potential. 2010, Pubmed
Hogg, Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control. 2007, Pubmed
Holland, Development of a defined medium supporting rapid growth for Deinococcus radiodurans and analysis of metabolic capacities. 2006, Pubmed
Izmirly, Neonatal lupus syndromes. 2007, Pubmed
Kato, Nucleotide sequence of 4.5S RNA (C8 or hY5) from HeLa cells. 1982, Pubmed
Kelekar, Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins. 1994, Pubmed
Köhn, Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNA. 2010, Pubmed
König, iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution. 2010, Pubmed
Labbé, The Caenorhabditis elegans rop-1 gene encodes the homologue of the human 60-kDa Ro autoantigen. 1995, Pubmed
Labbé, The levels of the RoRNP-associated Y RNA are dependent upon the presence of ROP-1, the Caenorhabditis elegans Ro60 protein. 1999, Pubmed
Labbé, ROP-1, an RNA quality-control pathway component, affects Caenorhabditis elegans dauer formation. 2000, Pubmed , Xenbase
Lee, Cutaneous lupus in infancy and childhood. 2010, Pubmed
Lee, The clinical spectrum of neonatal lupus. 2009, Pubmed
Lerner, Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. 1981, Pubmed
Licatalosi, HITS-CLIP yields genome-wide insights into brain alternative RNA processing. 2008, Pubmed
Liu, Reconstitution, activities, and structure of the eukaryotic RNA exosome. 2006, Pubmed
Maity, Compartmentalization directs assembly of the signal recognition particle. 2006, Pubmed
Malet, RNA channelling by the eukaryotic exosome. 2010, Pubmed
Mamula, The Ro ribonucleoprotein particle: induction of autoantibodies and the detection of Ro RNAs among species. 1989, Pubmed
Marshak-Rothstein, Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. 2007, Pubmed
Matsuoka, ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. 2007, Pubmed
Miller, Is there a correction mechanism in the 5S multigene system? 1978, Pubmed , Xenbase
Mohanty, Bacterial/archaeal/organellar polyadenylation. 2011, Pubmed
Mosig, Evolution of the vertebrate Y RNA cluster. 2007, Pubmed
O'Brien, A subset of hY RNAs is associated with erythrocyte Ro ribonucleoproteins. 1990, Pubmed
O'Brien, Xenopus Ro ribonucleoproteins: members of an evolutionarily conserved class of cytoplasmic ribonucleoproteins. 1993, Pubmed , Xenbase
O'Brien, A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors. 1994, Pubmed , Xenbase
Perreault, Ro-associated Y RNAs in metazoans: evolution and diversification. 2007, Pubmed
Peterson, Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNA. 1980, Pubmed , Xenbase
Pettersson, The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies. 1984, Pubmed
Prathapam, A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase. 2005, Pubmed
Pruijn, Analysis of protein--RNA interactions within Ro ribonucleoprotein complexes. 1991, Pubmed
Pruijn, Ro RNP associated Y RNAs are highly conserved among mammals. 1993, Pubmed
Ramesh, Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity. 2007, Pubmed
Reed, Autoantibodies to SS-A/Ro in infants with congenital heart block. 1983, Pubmed
Routsias, Autoimmune response and target autoantigens in Sjogren's syndrome. 2010, Pubmed
Scofield, Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. 2005, Pubmed
Scott, Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block. 1983, Pubmed
Shi, A misfolded form of 5S rRNA is complexed with the Ro and La autoantigens. 1996, Pubmed , Xenbase
Sim, The subcellular distribution of an RNA quality control protein, the Ro autoantigen, is regulated by noncoding Y RNA binding. 2009, Pubmed
Slobbe, Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these proteins. 1991, Pubmed
Slobbe, Ro ribonucleoprotein assembly in vitro. Identification of RNA-protein and protein-protein interactions. 1992, Pubmed
Sontheimer, Serologic and HLA associations in subacute cutaneous lupus erythematosus, a clinical subset of lupus erythematosus. 1982, Pubmed
Springer, Complement and the multifaceted functions of VWA and integrin I domains. 2006, Pubmed
Stein, Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. 2005, Pubmed , Xenbase
Stokes, Profiling of UV-induced ATM/ATR signaling pathways. 2007, Pubmed
Tanaka, Analysis of Deinococcus radiodurans's transcriptional response to ionizing radiation and desiccation reveals novel proteins that contribute to extreme radioresistance. 2004, Pubmed
Teunissen, Conserved features of Y RNAs: a comparison of experimentally derived secondary structures. 2000, Pubmed
Ule, CLIP: a method for identifying protein-RNA interaction sites in living cells. 2005, Pubmed
Van Horn, Caenorhabditis elegans embryos contain only one major species of Ro RNP. 1995, Pubmed , Xenbase
Vitali, Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. 2002, Pubmed
Voulgarelis, Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome. 2010, Pubmed
Werth, Photosensitivity in rheumatic diseases. 2004, Pubmed
Weston, The clinical spectrum of anti-Ro-positive cutaneous neonatal lupus erythematosus. 1999, Pubmed
Weston, A serological marker for neonatal lupus erythematosus. 1982, Pubmed
Wolin, The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure. 2006, Pubmed , Xenbase
Wolin, Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome. 1983, Pubmed
Wolin, The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs. 1984, Pubmed
Wurtmann, A role for a bacterial ortholog of the Ro autoantigen in starvation-induced rRNA degradation. 2010, Pubmed
Xue, A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. 2003, Pubmed
Yamagata, Molecular properties of the Ro/SSA antigen and enzyme-linked immunosorbent assay for quantitation of antibody. 1984, Pubmed